By D. J. Galas, T. B. L. Kirkwood, R. F. Rosenberger (auth.), T. B. L. Kirkwood, R. F. Rosenberger, D. J. Galas (eds.)
Molecular biology proceeds at unremitting velocity to spread new secrets and techniques of the dwelling global. Biology, lengthy considered as an inexact spouse to physics and chemistry, has gone through transformation. Now, chemical and actual rules are instruments in knowing hugely complicated biomolecular approaches, whose foundation lies in a heritage of likelihood, constraint and normal choice. The accuracy of those techniques, frequently remarkably excessive, is important to their self perpetuation, either separately and jointly, as parts of the organism as an entire. during this publication are provided 13 chapters which care for a number of points of the accuracy challenge. topics lined comprise: the specificity of enzymes; the constancy of synthesis of proteins; the replication and service of DNA: basic schemes for the enhancement of organic accuracy; choice for an optimum stability among the prices and merits of accuracy; and the potential relevance of molecular errors to the method of getting older. The viewpoints are detailed, but complementary, and the publication as an entire deals to researchers and scholars the 1st accomplished account of this becoming field.
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Extra resources for Accuracy in Molecular Processes: Its Control and Relevance to Living System
At the other extreme, the strong interactions of a chemical bond, with a stabilization of 250 kJ mol- l or more, may hold groups together with a specific, relatively rigid, geometry. Between these two limits are various interactions of intermediate strength which account for the cohesion and yet mobility of liquids, and for the existence of specific biologically important complexes such as those of antibody-antigen, hormone-receptor and enzyme-substrate. If A is a proton donor and B a proton acceptor then the complex AB may be created by the formation of a hydrogen bond between them.
W. (1980) The genetics of protein degradation in bacteria. Ann. Rev. , 14, 279-319. Murray, V. and Holliday, R. (1981) Increased error frequency of DNA polymerase from senescent human fibroblasts. 1. Mol. , 146, 55-76. Genetic information transfer Neidhardt, F. , van Bogelen, R. A. and Vaughn, V. (1984) The genetics and regulation of heat-shock proteins. Ann. Rev. , 18, 295-329. Ninio, J. (1975) Kinetic amplification of enzyme discrimination. Biochimie, 57, 587595. Orgel, L. E. (1963) The maintenance of the accuracy of protein synthesis and its relevance to ageing.
And Jones, P. A. (1983) DNA methylation decreases in ageing but not in immortal cells. Science, 220,1055-1057. Woolhouse, H. W. (1969) DNA polymerase, genetic variation and determination of the life span. In Proc. 8th Int. Congr. , Vol. 1, pp. 162-166. Federation of American Societies for Experimental Biology, Washington, DC. 35 3 The specificity of enzyme-substrate interactions M. I. 1 Introduction Molecules interact with one another. There is continual competition between their kinetic energies to be independent and the forces of intermolecular attraction to bring them together.
Accuracy in Molecular Processes: Its Control and Relevance to Living System by D. J. Galas, T. B. L. Kirkwood, R. F. Rosenberger (auth.), T. B. L. Kirkwood, R. F. Rosenberger, D. J. Galas (eds.)