Get Advanced Topics on Radiosensitizers of Hypoxic Cells PDF

By C. E. Smithen, C. R. Hardy (auth.), A. Breccia, C. Rimondi, G. E. Adams (eds.)

ISBN-10: 1475703996

ISBN-13: 9781475703993

ISBN-10: 1475704011

ISBN-13: 9781475704013

In July 1979, the college of Pharmacy of the collage of Bologna obtained a suggestion from Professor Breccia to carry a world convention on "Nitroimidazoles: Chemistry, Pharmacology and scientific Application." end result of the nice curiosity in those medicines in quite a few fields, i used to be more than happy to just accept the idea and to provide the convention the sponsorship of the college of Bologna. It was once an additional excitement to just accept the chairmanship of the assembly, including Professors Sensi and Adams. while, the Minister of schooling licensed a suggestion which additionally got here from the school of Pharmacy, to provide a sophisticated direction at the subject "Radiosensitizers of Hypoxic Cells This path was once for that reason authorized via a unique Committee of the NATO clinical Programme as a complicated examine Institute. because the material of either the convention and the direction are heavily inter-related, it was once logical to devise the convention as a part of the general path. Bringing jointly experts from rather varied and it seems that unrelated fields of analysis, yet all with an curiosity within the research and alertness of 1 unmarried team of gear, is a unique thought with exciting chances. The volumes of the lawsuits comprise contributions from specialists with such assorted pursuits as man made chemistry, mechanism of drug motion, parasitology, anaerobic micro organism and protozoa, pharmacology and toxicology, radiation sensitizers to be used in radiotherapy, and the improvement of gear to be used in melanoma in general.

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About a year ago Harmon described some 2- and 4-nitroimidazole derivatives of 2'-deoxyribonucleosides, obtained by reacting nitroimidazole metal salts with 5'-halogeno of 5'-tosyloxy-2'-deoxyribonucleosides [R E Harmon, J L Hansen and M Gortiz, Synthesis of some radiosensitizing agents, Abstract CARS-51, 178th Meeting Amer. Chem. g. fiN 'N~N02 I o~E OH I have no further information on the chemical or radiosensitizing properties of these compounds and the only other nitroimidazole glycoside that has been studied as a hypoxic cell radiosensitizer, to my knowledge, is the azomycin-riboside of Townsend 16 which was investigated by Dr J D Chapman at Edmonton, Canada [data subsequently presented at this Conference].

7:211 (1970). 72. P. M. Kochergin, A. M. Tsyganova, V. S. Shlikhunova and M. A. Klykov, Imidazoles LVI. Nucleophilic substitution of 4(5)-nitro-5(4)-chloro or bromoimidazoles (Russian), Khim. Geterotsikl. , 7:689 (1971). 73. L. F. Miller and R. E. Bambury, 2-Amino-5-nitroimidazoles, J. Med. , 14:1217 (1971). 74. F. F. Blicke and C. M. Lee, Derivatives of 7-methyl-6-thia-l,6dihydro and 7-methyl-6-thia-l,2,3,6-tetrahydropurine-6,6dioxide, J. Org. , 26:1861 (1961). 75. R. C. Tweit, E. M. Kreider and R.

Beaman, W. Tautz and R. Duschinsky, Studies in the nitroimidazole series III. ed. in the I-position, Antimicrobial Agents and Chemotherapy 1967, 520 (1968). A. G. Beaman and W. ), U. S. Patent 3,793,317 (1974). A. G. , AG), U. K. Patent 1,066,409 (1967). C. E. ), U. K. Patent 2,003,154 (1979). C. E. Smithen, unpublished data, Synthesis, chemistry and metabolism of misonidazole and closely related 2-nitroimidazoles (Poster), presented at 6th Internat. Symposium on Medicinal Chemistry, Brighton, U.

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Advanced Topics on Radiosensitizers of Hypoxic Cells by C. E. Smithen, C. R. Hardy (auth.), A. Breccia, C. Rimondi, G. E. Adams (eds.)


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