Advancements of Mass Spectrometry in Biomedical Research by Alisa G. Woods, Costel C. Darie PDF

By Alisa G. Woods, Costel C. Darie

ISBN-10: 3319060678

ISBN-13: 9783319060675

ISBN-10: 3319060686

ISBN-13: 9783319060682

This quantity explores using mass spectrometry for biomedical functions. Chapters concentrate on particular healing components similar to oncology, infectious affliction and psychiatry. extra chapters specialise in method in addition to new applied sciences and instrumentation. This quantity offers readers with a accomplished and informative guide that might let them savor mass spectrometry and proteomic study but additionally to start up and increase their very own paintings. therefore the booklet acts as a technical consultant but in addition a conceptual advisor to the latest info during this interesting field.

Mass spectrometry is the significant software utilized in proteomic learn this day and is speedily changing into necessary to the biomedical scientist. With the of entirety of the human genome undertaking and the genomic revolution, the proteomic revolution has heavily at the back of. realizing the human proteome has develop into serious to easy and scientific biomedical examine and holds the promise of supplying complete figuring out of human physiological approaches. moreover, proteomics and mass spectrometry are bringing extraordinary biomarker discovery and are supporting to customize medicine.

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7). A top-down approach allows for the identification of protein isoforms or any potential PTMs within proteins [65]. In bottom-up approach, digested proteins are subjected to MS analysis using on-line tandem mass spectrometry (MS/MS). In the same bottom-up approach, peptide mass fingerprinting for protein identification is also used, particularly in MALDI-MS analyses. In a variation of bottom-up proteomics, known as shotgun proteomics, a large protein mixture is digested, and the resulting peptides are fractionated by onedimensional or multidimensional chromatography and further analyzed by MS/MS [66].

Mod Chem Appl 1:e105 10. Darie CC (2013) Mass spectrometry and its application in life sciences. Aust J Chem 66:1–2 11. Ngounou Wetie AG, Sokolowska I, Woods AG, Darie CC (2013) Identification of posttranslational modifications by mass spectrometry. Aust J Chem 66:734–748 12. Ngounou Wetie AG, Sokolowska I, Woods AG, Roy U, Deinhardt K, Darie CC (2014) Protein-protein interactions: switch from classical methods to proteomics and bioinformaticsbased approaches. Cell Mol Life Sci 71(2):205–228 1 Mass Spectrometry for Proteomics-Based Investigation 25 13.

Dass C (2007) Fundamentals of contemporary mass spectrometry. Wiley-Interscience, Hoboken, NJ 49. Hoffmann ED, Stroobant V (2007) Mass spectrometry: principles and applications, 3rd edn. J. Wiley, Chichester, West Sussex, England 50. Abate S, Ahn YG, Kind T, Cataldi TR, Fiehn O (2010) Determination of elemental compositions by gas chromatography/time-of-flight mass spectrometry using chemical and electron ionization. Rapid Commun Mass Spectrom 24:1172–1180 51. Harrison AG (1992) Chemical ionization mass spectrometry, 2nd edn.

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Advancements of Mass Spectrometry in Biomedical Research by Alisa G. Woods, Costel C. Darie

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