By Jesse P. Greenstein and Alexander Haddow
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Extra info for Advances in Cancer Research, Vol. 2
40. Stora et al. (1947) found after reaction of mustard gas with gliadin, ovalbumin, serum albumin, oxyhemoglobin, and casein that for each atom of sulfur introduced the proteins contained approximately one atom of chlorine. , that the- product Protein -(CHZ)~-S(CHz)z C1 was obtained. Peters and Wakelin (1947) also found chlorine in mustard-treated kerateine, but observed that the amount decreased when the protein was washed for long periods with water. They attribute this to the slow hydrolysis of the chloroalkyl group introduced.
These experiments indicate the possibility of main chain breakdown of DNA by this reaction: \R 0 ‘ d 0- -0I R ,o / tf‘ R ‘ ‘ 0 + Mustard(M) -+ /” / A I 0 ‘ -0-M b slow hydrolysis I P-0-M I + -RH cjH C. Interference with the Combination with Protamine. , deswell) when placed in solution of polybases such as polyethyleneimines and protamines, and this was attributed to the formation of a complex held together by salt links, the dissociation of which is prevented by the van der Waals forces between the macromolecules.
65) since their effect might be comparable t o the accumulation of a highly insoluble metabolic product. 4. The in situ Polymerization Hypothesis Hendry et al. (1950, 1951a,b,c) suggest that the cytotoxic alkylating agents polymerize in situ to give a macromolecule containing reactive groups. The necessity for two functional groups, according to this hypothesis, arises from the fact that one brings about the joining up of THE REACTIONS OF CARCINOQENS WITH MACROMOLECULES 21 the molecules into a polymer and the second group provides the reactive centers in the polymer.
Advances in Cancer Research, Vol. 2 by Jesse P. Greenstein and Alexander Haddow