By Sudarshan K. Malhotra
A part of a chain which goals to hide fresh wisdom within the box of neural technological know-how, this quantity discusses such issues as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.
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Extra info for Advances in Neural Science, Volume 2 (Advances in Neural Science)
Embryos treated with GHRH in ovo on embryonic days 1,3, 5, and 7 exhibit a significant increase in TH activity. Similar results are obtained when GHRH is administered in a single dose on day 1 or day 3 but not on day 5 of development. The influence of GHRH on catecholalminergic neuronal expression appears to be GHRH-mediated and not through its influence on growth hormone (GH), since growth hormone administration during the same critical period produces no changes in TH activity (Kentroti and Vernadakis, 1989).
The role of GHRH as a neuromodulator has only recently been investigated with the report of Rivier et al. , 1988). Based on our findings (Kentroti and Vernadakis, 1989), GHRH may be a neuromodulator involved in the maturation of catecholaminergic neurons. , 8-day-old embryos exhibited a level of TH activity equal to that in 10-day-old embryos). The possibility that GHRH may shift the time course of neuronal maturation warrants consideration. Endogenous peptides have been shown to mediate the time course of developmental events.
1986). Miyoshi et al. (1989), using hippocampal neuronal cultures prepared from 18-day rat embryos, found that SRIF increases intracellular Ca 2+ concentration in a dose-dependent manner. Since this increase appears to be inhibited by 0)-conotoxin GVIA, a neurotoxic peptide from the venom of a marine snail, it is suggested that SRIF receptors may be coupled with N-type volgate-sensitive Ca 2+ channels in cultured hippocampal neurons. B. Vasoactive Intestinal Polypeptide Early studies by Taylor and Pert (1979) showed specific binding of VIP to adult rat brain membranes.
Advances in Neural Science, Volume 2 (Advances in Neural Science) by Sudarshan K. Malhotra