Download e-book for kindle: Advances in Pharmacology and Chemotherapy Volume 13 by Silvio Garattini

By Silvio Garattini

ISBN-10: 0080581048

ISBN-13: 9780080581040

ISBN-10: 0120329131

ISBN-13: 9780120329137

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Additional resources for Advances in Pharmacology and Chemotherapy Volume 13

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P. (1963). Rev. Inst. Med. Trop. Sao Paulo 5, 243-248. Cuckler, A. , Kupferberg, A. , and Millman, N. (1955). Antibiot. Chemother. ) 5 , 540-550. , and Foltinova, P. (1971). In “Advances in Antimicrobial and Anti-neoplastic Chemotherapy” , pp. 417418. Ebringer. , and h e m e c , P. (1964). J. Protozool. 11, 153-156. Fernandes, J. , and Castellani, 0. (1958). Exp. Parasitol. 7, 224-235. Fernandes, J. , and Castellani, 0. (1959). Exp. Parasitol. 8, 480485. Fernandes, J. , and Castellani, 0. (1966).

This might be a selective action, since 8-aminoquinolines do not hinder nucleic acid synthesis in plasmodia (Schellenberg and Coatney, 1961). The second group of compounds likely to exhibit similar activity would be the 5-nitrofurans which, at least in bacteria, are good electron acceptors and inhibit a number of dehydrogenases (Jaffe, 1968). Santos (1962) demonstrated, by polarographic studies, inhibition of the respiration of T . cruzi culture forms by different nitrofuran compounds and suggested these drugs to be strong inhibitors of glucose active transport.

The apparent dependence of T. cruzi on exogenous bases has suggested the chemotherapeutic uses of purine and pyrimidine analogs to inhibit the normal biosynthesis of nucleotides and nucleic acids. The aminonucleoside of stylomycin, for instance, works this way, inhibiting the incorporation of adenine into purine nucleotides (Fernandes and Castellani, 1959, 1968). , 1959). , 1965; Castellani and Fernandes, 1965). A study of the effects of several purine and pyrimidine analogs on growth rate and nucleic acid synthesis in T.

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Advances in Pharmacology and Chemotherapy Volume 13 by Silvio Garattini

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