By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)
F. M. MUGGIA whilst confronted with the inadequacies of present melanoma remedy, we like to examine what the longer term may perhaps carry. generally, we take with no consideration the previous, who prefer study into absolutely new parts. despite the fact that, the power improvement of fertile soil may well yield incredible rewards when you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even though the anthracycline antibiotics symbolize a lot of the current and way forward for melanoma therapy, their genuine use c stretches again slightly twenty years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor houses of daunomycin and adriamycin. * The scientific software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new desire for sufferers with sar comas and various different tumors that were deemed - sistant to chemotherapy. those successes have been tempered with the belief that the antitumor influence of anthracyclines can be completed every now and then in basic terms on the very excessive cost of risking cardiac decompensation and, nearly normally, with the prevalence of alopecia and different acute toxicities. This checklist of prior achievements and difficulties has slowly given option to a gift more and more illuminated via our skill to change the distressing toxicities of those brokers. designated medical reviews supplemented by way of creative laboratory versions have progressively elucidated mechanisms and danger components im plicated within the cardiomyopathy.
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Additional resources for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981
In these experiments, the superiority of DX versus DNR is particularly evident. v. against spontaneous and transplanted mammary carcinoma of C3H mice; DX produces inhibition of tumor development 9Pd regression of already established tumors up to 90%. v. treatment, the most'effective treatment being every other day x 12 with a low dose (~s reported in Table 2), or treatment on a weekly schedule for 3-4 weeks with a higher dose (6 rrg/kg) (11). 15 Table 2. Comparison of DX with DNR against mouse solid tumors ONR Tumor Sarcoma 180 Transplanted mammary ca.
Procedures according to reference no. 8. 44 5. CONCLUSIONS The existing data demonstrate the high oncogenic potential of most of the anthracycline antitumor antibiotics. Such results suggest that patients treated with these substances should be closely monitored in anticipation of the possible appearance of newly induced tumors and that the drugs should be restricted to the therapy of diseases with poor prognosis. The mechanisms of action by which anthracyclines elicit their oncogenic effects are unknown.
Casazza AM. 3. Arcamone F, Casazza AM, Cassinelli G, Oi Marco A, Penco S. Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, September 16-18, 1981. 4. Sandberg JS, Howsden FL, Di Marco A, Goldin A. 1970. Cancer Chemother. , 54, 1. 27 5. Kitaura K, Watanabe Y. 1972. Jap. J. , ~, 65. 6. Di Marco A, Casazza AM, Giuliani F, Pratesi G, Arcamone F, Bernardi L, Franchi G, Giardino P, Patelli B, Penco S. 1978. Cancer Treat. , 62, 375. 7. Schwartz HS, Grindey GB. 1973. , 33,1837.. 8. Goldin A.
Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981 by F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)