By Greet Brouckaert, Michael Kalai (auth.), Marek Los, Spencer B. Gibson (eds.)
As our figuring out of apoptotic pathway expands, we're coming to gain the good strength of using this pathway to regard ailments corresponding to melanoma. The ebook makes an attempt to check, summarize, and speculate at the apoptotic pathways, how are they regulated and the way special treatments are getting used to regard a large choice of illnesses. unique emphasis is put on melanoma on the grounds that new remedies both being constructed or at present within the scientific atmosphere are displaying nice promise to extend survival charges for melanoma sufferers. Chapters will deal with the biology in the back of regulating the apoptotic pathways and what is going incorrect in affliction states while different chapters will be aware of new treatments focusing on apoptotic pathways. The reader by means of the top of the ebook must have better perception into the knowledge and usage of apoptotic pathways to struggle illnesses comparable to melanoma.
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Extra info for Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases
Jaattela M, Cande C & Kroemer G. (2004). Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF. Cell Death Differ, 11:135-6. , (2004). RAIDD aggregation facilitates apoptotic death of PC 12 cells and sympathetic neurons. Cell Death Differ, 11:618-30. Jan Y, Matter M, Pai JT, et al, (2004). A mitochondrial protein, Bitl, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell, 116:751-62. Jimbo A, Fujita E, Kouroku Y, et al, (2003).
J Biol Chem, 278:31401-11. Boatright KM, Renatus M, Scott PL, et al, (2003). A unified model for apical caspase activation. Mol Cell, 11:529-41. Bodmer JL, Schneider P, & Tschopp J. (2002). The molecular architecture of the TNF superfamily. Trends Biochem Sci, 21:19-26. Boldin MP, Goncharov TM, Goltsev YV, et al, (1996). Involvement of MACH, a novel MORTl/FADDinteracting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell, 85:803-15. Bouillet P & Strasser A. (2002). BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.
Cancer Cell, 2:183-92. Leu JI, Dumont P, Hafey M, et al, (2004). Mitochondrial p53 activates Bak and causes disruption of a BakMcll complex. Nat Cell Biol, 6:443-50. Levine B & Klionsky DJ. (2004). Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell, 6:463-77. Li F. (2003). Survivin study: what is the next V/SLWQ'} J Cell Physiol, 197:8-29. Li H, Zhu H, Xu CJ, et al, (1998). Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases by Greet Brouckaert, Michael Kalai (auth.), Marek Los, Spencer B. Gibson (eds.)