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By Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)

ISBN-10: 0683061542

ISBN-13: 9780683061543

ISBN-10: 1461475295

ISBN-13: 9781461475293

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The observation that both acetylcholine and catecholamines alter the ANP-secretion rate implies that autonomic nerves participate in the regulation of this hormone. Recently Ledsome and co-workers (20) addressed this question in studies in the dog. They observed that electrical stimulation of the right ansa subclavia did not change plasma ANP levels, although heart rate increased by 100 beats/min. This is somewhat surprising, because other studies show that ANP secretion is dependent on the rate of depolarization.

Physiol. Paris 51: 393-396, 1959. 3. BERRIDGE, M. J. Inositol trisphosphate and diacylglycerol as second messengers. Biochem. J. 220:345-360,1984. 4. , R. L. MALVIN, K. E. JOCHIM, AND D. E. ROBERTS. Influence of right and left atrial receptors on plasma concentrations of ADH and renin. Am. J. Physiol. 221: 273-278, 1971. 5. , AND J. GENEST. The heart and the atrial natriuretic factor. Endocr. Rev. 6: 107127,1985. 6. DE BOLD, A. , H. B. BORENSTEIN, A. T. VERESS, AND H. SONNENBERG. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats.

Sci. USA 78: 33633367, 1981. 34. SEIDMAN, C. , K. D. BLOCH, J. ZISFEIN, J. A. SMITH, E. HABER, C. HOMCY, A. D. DUBY, E. CHOI, R. M. GRAHAM, AND J. G. SEIDMAN. Molecular studies of the atrial natriuretic factor gene. Hypertension Dallas 7, Suppl. I: 131-134, 1985. 35. SHAMOO, A. , AND I. S. AMBUDKAR. Regulation of calcium transport in cardiac cells. Can. J. Physiol. Pharmacal. 62: 9-22, 1984. 36. , R. S. SIDER, E. A. 0STAFIN, AND R. J. GREKIN. Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.

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Atrial Hormones and Other Natriuretic Factors by Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)


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