By Mark A. Israel (auth.), Kazuo Tabuchi M. D. (eds.)
Growth job of mind tumors, metabolism of mind tumors, mind tumors and cytokines, drug resistance of mind tumors, oncogenes and anti-oncogenes, simple experiences in mind tumor biology and treatment are offered during this book.
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Extra resources for Biological Aspects of Brain Tumors: Proceedings of the 8th Nikko Brain Tumor Conference, Karatsu (Saga) 1990
Proc Natl Acad Sci USA 84: 5419-5423 8. Logan JA, Seizinger BR, Atkins L, Martuza RL (1990) Loss of the Y chromosome in meningiomas: A molecular genetic approach. Cancer Genet Cytogenet 45:41-47 9. Dumanski JP, Rouleau GA, Nordenskjold M, Collins VP (1990) Molecular genetic analysis of chromosome 22 in 81 cases of meningioma. Cancer Res 50:5863-5867 10. Bigner SH, Mark J, Mahaley MS Jr, Bigner DD (1984) Patterns of the early, gross chromosomal changes in malignant human gliomas. Hereditas 101:103-113 11.
Other mutants with compromised neurovirulence are worthy of testing and the construction of viruses containing several mutations may further decrease neurovirulence while retaining the desired properties of glioma cell killing. Other mechanisms of cell selectivity may also be explored, including the use of cell-specific promoters for genes essential for viral replication. Additionally, the herpes virus has a much larger genome than retroviruses, thus the ability to use the herpes system not only for cell killing but also for gene transfer and cell modulation should also be considered.
Science 236:317-319 5. Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Seizinger BR, Martuza RL, Supemeau OW, Conneally PM, Gusella JF (1987) Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 329:246-248 Genetic Alterations of Nervous System Tumors 25 6. Rouleau GA, Seizinger BR, Wertelecki W, Haines JL, Superneau DW, Martuza RL, Gusella JF (1990) Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22. Am J Hum Genet 46:323-328 7.
Biological Aspects of Brain Tumors: Proceedings of the 8th Nikko Brain Tumor Conference, Karatsu (Saga) 1990 by Mark A. Israel (auth.), Kazuo Tabuchi M. D. (eds.)