By Jeffrey Tobias, Daniel Hochhauser(auth.)
Now in its 6th variation, this highly-regarded e-book is designed as an introductory textual content at the rules of prognosis, staging and remedy of tumours. the hot version:
- Includes up to date details at the most up-to-date innovations and cures to be had
- Emphasises the significance of multidisciplinary teamwork within the care of melanoma sufferers
- Highlights widespread dilemmas and problems encountered in the course of melanoma administration
- Features the real contributions of a brand new writer Professor Daniel Hochhauser
- Contains a brand-new two-colour layout
As with prior variants, the 1st a part of the e-book is dedicated to the mechanisms of tumour improvement and melanoma therapy. this is often by way of a scientific account of the present administration of person significant cancers. for every tumour there are info of the pathology, mode of unfold, medical presentation, staging and therapy with radiotherapy and chemotherapy.
This obtainable and functional source might be worthwhile to trainees in oncology, palliative care and common drugs, in addition to professional nurses, basic practitioners, scientific scholars, and professions allied to medicine.Content:
Chapter 1 the trendy administration of melanoma: An Introductory observe (pages 1–6):
Chapter 2 Epidemiology, healing, remedy Trials and Screening (pages 7–24):
Chapter three Biology of melanoma (pages 25–42):
Chapter four Staging of Tumours (pages 43–57):
Chapter five Radiotherapy (pages 58–76):
Chapter 6 Systemic remedy for melanoma (pages 77–106):
Chapter 7 Supportive Care and Symptom reduction (pages 107–121):
Chapter eight scientific difficulties and Radiotherapy Emergencies (pages 122–138):
Chapter nine Paraneoplastic Syndromes (pages 139–147):
Chapter 10 melanoma of the pinnacle and Neck (pages 148–172):
Chapter eleven mind and Spinal wire (pages 173–196):
Chapter 12 Tumours of the Lung and Mediastinum (pages 197–222):
Chapter thirteen Breast melanoma (pages 223–253):
Chapter 14 melanoma of the Oesophagus and abdominal (pages 254–268):
Chapter 15 melanoma of the Liver, Biliary Tract and Pancreas (pages 269–284):
Chapter sixteen Tumours of the Small and massive Bowel (pages 285–296):
Chapter 17 Gynaecological melanoma (pages 297–327):
Chapter 18 Genitourinary melanoma (pages 328–356):
Chapter 19 Testicular melanoma (pages 357–373):
Chapter 20 Thyroid and Adrenal melanoma (pages 374–387):
Chapter 21 melanoma from an Unknown fundamental web site (pages 388–392):
Chapter 22 dermis melanoma (pages 393–410):
Chapter 23 Bone and Soft?Tissue Sarcomas (pages 411–431):
Chapter 24 Paediatric Malignancies (pages 432–454):
Chapter 25 Hodgkin's illness (pages 455–472):
Chapter 26 Non?Hodgkin's Lymphomas (pages 473–499):
Chapter 27 Myeloma and different Paraproteinaemias (pages 500–513):
Chapter 28 Leukaemia (pages 514–536):
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Extra resources for Cancer and its Management, 6th Edition
This has involved the use of historical controls which compare a new treatment to patients treated in the past. An attempt is normally, but not always, made to match the controls for age, sex, site and stage of tumour, and other known prognostic factors such as histological grade and menopausal status. The problems are that staging methods are changing continually, that selection of control cases may not be impartial and that not all prognostic factors will be known. These studies may sometimes point the way in management and indicate which questions should be asked in large-scale prospective studies.
Population mixing and childhood leukaemia: Fallon and other US clusters. Br J Cancer 2004; 91: 1–3. 6 Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med 2003; 348: 1625–38. 7 Sproston K, Primatesta P, eds. Health Survey for England 2002 vol. 1: The Health of Children and Young People. London: The Stationery Office, 2003. 8 Bjelakovic G, Nikolova D, Simonetti RG et al. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis.
DNA repair is thus central to the process of carcinogenesis. Many of the hereditary cancer syndromes have been shown to be due to mutation in essential DNA repair genes, resulting in impaired repair over a lifetime. The process of repair is through several mechanisms. The processes are essential mechanisms for survival for all living cells. Actively transcribed genes are repaired more efficiently than inactive genes. In base excision repair the abnormal DNA base is excised enzymatically, first by endonucleases which cleave the DNA strand, then by exonucleases which remove the abnormal segment, followed by the action of a polymerase which resynthesizes the missing segment.
Cancer and its Management, 6th Edition by Jeffrey Tobias, Daniel Hochhauser(auth.)