Read e-book online Cancer Chemotherapy: Concepts, Clinical Investigations and PDF

By Neil W. Gibson (auth.), F. M. Muggia (eds.)

ISBN-10: 1461289815

ISBN-13: 9781461289814

ISBN-10: 1461317479

ISBN-13: 9781461317470

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Activities of thymidylate synthase in human colon adenocarcinoma xenografts. At various times between 4 and 72 h after injection of FUra (100 mg/kg), tumors were excised and four tumors were pooled for each time point. Thymidylate synthase activity in untreated and FUra-treated tumors was determined after removal of endogenous dUMP. ) HxVRC s , (6) HxGC" and (0) HxELC 2 . From Houghton et al. [37]. Although dUMP does not displace FdUMP from thymidylate synthase, or alter the rate of dissociation of FdUMP from the ternary complex [42], it could protect newly synthesized enzyme from inactivation by competing with FdUMP for binding or, alternatively, could prevent FdUMP from rebinding once dissociation had occurred.

Q Rev Biophys 14:289-380, 1981. : Clinical antitumor activity and toxicity of streptozotocin (NSC 85998). Cancer 34:993-1000, 1974. Gibson NW, Hartley JA, Barnes D, and Erickson LC: Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype. Cancer Res 46: 4995-4998, 1986. Hartley JA and Gibson NW: DNA damage and cytotoxicity of2-chloroethyl(methylsulfonyl) methane-sulfonate (NSC-338947) produced in human colon carcinoma cells with or without methylating agent pretreatment.

Kufe DW, Major PP, Egan EM, and Loh E: 5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA. 1 BioI Chern 256:8885-8888, 1981. 3l. Schuetz lD, Wallace Hl, and Diasio RB: 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Res 44:1358-1363, 1984. 32. Ingraham HA, Tseng BY, and Goulian M: Mechanism for exclusion of 5-fluorouracil from DNA. Cancer Res 40:998-1001, 1980. 33. Goulian M, Bleille B, and Tseng BY: Methotrexate-induced misincorporation of uracil into DNA.

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Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances by Neil W. Gibson (auth.), F. M. Muggia (eds.)


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