Cancer in Children: Clinical Management - download pdf or read online

By R. W. Miller (auth.), Paul A. Voûte, Ann Barrett, H. Julian G. Bloom, Jean Lemerle, Malte K. Neidhardt (eds.)

ISBN-10: 354015342X

ISBN-13: 9783540153429

ISBN-10: 3642968899

ISBN-13: 9783642968891

Cancer in kids is the 1st quantity during this new sequence, backed via the DICC, at the therapy of melanoma. The editors and authors think strongly that extra standardization is required on a world foundation in melanoma remedy. This, after all, is just attainable if specialists from all international locations join a joint coverage of creating their remedy designs to be had to practicing oncologists around the world. present therapy of melanoma will speak about the entire gear and techniques now in use in melanoma treatment. it's going to conceal every kind of melanoma, hence offering the reader with finished details on melanoma deal with­ ment. the looks of a publication on paediatric oncology because the first within the sequence is intentional: in contemporary a long time there was a massive development within the therapy of melanoma in young children, and there's desire for even additional luck during this struggle. we're confident that this e-book and the sequence it truly is introducing can help us to make a concerted reaction to the problem of cancer.

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Starn K, Heisterkamp N, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J (1985) Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and Philadelphia chromosome. N Engl J Med 313: 1429-1433 35. ISCN: An international system for human cytogenetic nomenclature (1978) Cytogenet Cell Genet 21: 309-404 36. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the adult leukaemias. Br J Haematol 33: 451-458 3.

Cowan KH, Myers CE, Chabner DA (1981) Drug monitoring in antineoplastic therapy. In: Richen A, . Marks V (eds) Therapeutic drug monitoring. Churchill Livingstone. Edinburgh, pp 471-481 9. CurtGA, Clendeninn NJ, ChabnerBA (1984) Drug resistance in cancer. Cancer Treat Rep 68: 87-99 10. Goldie IN, Coldmann AJ (1984) The genetic origin of drug resistance in neoplasms: implications for systemic therapy. Cancer Res 44: 3643-3653 11. Olive D, Morali A, Bordigoni P, Benz E, Peeters M (1985) Intestinal side-effects of chemotherapy in childhood: data of 116 jejunal biopsies; a rational basis for nutritional support.

Bleomycin gives rise to lesions similar to those seen with oxygen toxicity; they are dose dependent and aggravated by pulmonary irradiation. To avoid this complication the cumulative dose should not exceed 250 mg/m 2. With doses of 450 mg/m 2 10%-20% of patients will be affected. Metaplasia of type II pneumocytes, intra-alveolar and interstitial oedema and fibrosis occur and may be irreversible and fatal in up to 50/~ of patients. A similar picture is seen with nitrosoureas in doses of 1000-1500 mg/m2, mitomycin C, busulphan, cyclophosphamide, chlorambucil and methotrexate.

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Cancer in Children: Clinical Management by R. W. Miller (auth.), Paul A. Voûte, Ann Barrett, H. Julian G. Bloom, Jean Lemerle, Malte K. Neidhardt (eds.)

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