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By Catherine Adell O'Brien, Antonija Kreso, and Catriona H.M. Jamieson

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Neuroendocrinology 40:272276, 1985. , Vulliez-Ie Normand, B. and Dray, F. Prostaglandins 35:969-976, 1988. TRANSCELLULAR BIOSYNTHESIS OF LEUKOTRIENES: IS LEUKOTRIENE A4 A MEDIATOR? C. MURPHY, J. M. HENSON National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206 USA and INSERM Unite 150, UA 334 CNRS, Hopital Lariboisiere, 75475 Paris Cedex 10, France INTRODUCTION The enzymatic steps involved in the synthesis of prostaglandins, thromboxanes, and leukotrienes have been elucidated in substantial detail in numerous biochemical studies (1,2).

7. 8. 9. 10. 11. 12. 13. 14. Ann. Rev. Biochem. 42:997-1029, 1978. Lewis, RA. and Austen, K. F. J. Clin. Invest. 73:889 (1984). E. Pharmacol. Res. 21:241-145,1989. , and Samuelsson, B. Proc. Natl. Acad. Sci. USA 71 :345,1975. W. Nature. 286:264, 1981. P. Pharmacol. Rev. 40:49,1989. Marcus, A. , and Islam, N. Biochem. Biophys. Res. Commun. 109:130, 1982. McGee, J. E. and Fitzpatrick, FA Proc. Natl. Acad. Sci. USA 83:1349,1986. Feinmark, S. J. : J. BioI. Chem. 261 :16466,1986. Maclouf, J. and Murphy, RC.

J. BioI. Chem. 261 :16466,1986. Maclouf, J. and Murphy, RC. J. BioI. Chem. 263:174-181, 1988. , and Baggiolini, M. J. BioI. Chem. 263:16179-16184,1988. M. Blood 74:703-707, 1989. J.. BioI. Chem. 257:4680-4683, 1982. C. J. , 143 :3680-3685,1989. THE OCCURENCE OF THROMBOXANE SYNTHASE IN TUMOR CELLS lR. NUSING, 1V. ULLRICH, 2F. J. MIHATSCH 1Faculty of Biology, University of Konstanz, FRG, 21nstitute of Pathology, University of Basel, CH INTRODUCTION Different studies have shown, that human tumors are able to synthesize prostanoids (1-3) with significant increases in production during tumor development (4,5).

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Cancer Stem Cells and Self-renewal (Article) by Catherine Adell O'Brien, Antonija Kreso, and Catriona H.M. Jamieson

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