By Antonio Giordano, Kenneth J. Soprano
Major clinicians and investigators overview in a understandable and straightforward type all of the most recent information regarding the molecular biology of phone cycle keep watch over and display its medical relevance to realizing neoplastic ailments. issues variety from Cdk inhibitors and mobile cycle regulators to the prognostic price of p27 and tumor suppressor genes as diagnostic instruments. real case experiences convey how the recent molecular knowing has produced such medications as Flavopiridol and Sulindac. The publication brings all of the contemporary serious examine findings to undergo on scientific perform, and obviously indicates their strong influence at the diagnostics, prognostics, and therapeutics of melanoma, AIDS, and heart problems.
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Additional info for Cell Cycle Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)
Fine mapping of the chromatin structure of a cell cycle-regulated human H4 histone gene. J Biol Chem 1989;264:1232–1237. 65. Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev 2000;14:2283–2297. 66. Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD, et al. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
The entry of a cell into S phase is tightly controlled near the end of G1 by key protein phosphorylation events, as the entry into M phase is controlled near the end of G2 (1). The central decision-making machinery, known as the “cell cycle clock,” which governs the cell’s fate, is able to respond in normal situations to growth factor stimulation only during the first two-thirds of the G1 phase. At the end of this period (restriction [R] point), the cells will continue the cycle, reenter the quiescent G0 phase, attain a postmitotic differentiated state, or die (2).
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins. Oncogene 1998;17:3463–3469. 38. Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC, Hinds PW. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Molec Cell 2001;8:303–316. 39. Hickey RJ, Malkas LH. Mammalian cell DNA replication. Crit Rev Eukaryot Gene Expr 1997;7:125–157. 40. Stillman B. Cell cycle control of DNA replication. Science 1996;274:1659–1664.
Cell Cycle Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) by Antonio Giordano, Kenneth J. Soprano