Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide - download pdf or read online

By Philip K. Moore, Matt Whiteman

ISBN-10: 3319181432

ISBN-13: 9783319181431

ISBN-10: 3319181440

ISBN-13: 9783319181448

This ebook places hydrogen sulfide in context with different gaseous mediators comparable to nitric oxide and carbon monoxide, experiences the to be had mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a large choice of affliction states. Hydrogen sulfide has lately been came across to be a evidently taking place gaseous mediator within the physique. Over a comparatively brief time period this evanescent fuel has been published to play key roles in a number of physiological techniques together with regulate of blood vessel quality and for that reason blood strain and within the rules of nerve functionality either within the mind and the outer edge. issues about the biosynthesis or job of hydrogen sulfide can also predispose the physique to disorder states akin to irritation, cardiovascular and neurological problems. curiosity during this novel gasoline has been excessive lately and lots of study teams around the globe have defined its person organic results. in addition, medicinal chemists are commencing to synthesize novel natural molecules that unlock this fuel at outlined premiums as a way to exploiting those new compounds for healing benefit.

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Extra resources for Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Example text

1 Reaction with Sulfenic Acids . . . . . . . . . . . . . . . . . . . . . . . . . 2 Reaction with S-Nitrosothiols . . . . . . . . . . . . . . . . . . . . . . . . . 3 Reaction with Disulfides . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Nonenzymatic S-sulfhydration by Species Originating from H2S . . . . . . . . . . 1 Reaction with Polysulfides . . . . . . . . . . . . . . . . .

2 Reaction with S-Nitrosothiols . . . . . . . . . . . . . . . . . . . . . . . . . 3 Reaction with Disulfides . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Nonenzymatic S-sulfhydration by Species Originating from H2S . . . . . . . . . . 1 Reaction with Polysulfides . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Reaction with Metal Centres and Generation of HS• . . . . . . . . . .

Filipovic a) b) CSE Healthy cell H2S parkin S-SH p50 p65 S-SH Nucleus Parkinson's disease Ub TNF rps3 Ub Ub parkin SNO rps3 p50 proteosomal degradation S-SH p65 antiapoptotic genes SP1 CSE transcription c) d) H2S H2S H2S HS HS HOS HS HS-S Keap1 Nrf-2 O3S ROS ROS Keap1 Nrf-2 HS-S H2S HS-S O3S-S ROS Nrf-2 Antioxidant defense Enzymatic cleavage SO32- HS NUCLEUS Fig. 6 Biological role of protein persulfidation.

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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by Philip K. Moore, Matt Whiteman


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