By Michael B. Sporn (auth.), Michael B. Sporn (eds.)
It is now obvious that a number of fields of research are converging upon one another because the objective of discovering a realistic approach to hinder melanoma is pursued. the current monograph represents the efforts of an interdisciplinary ESO activity strength that was once convened to evaluate interactions of peptide development elements and steroid-like molecules within the prevention of melanoma. all of the members within the activity strength represents a differentscientific self-discipline, and the monogrph is meant to be a synthesis in their assorted techniques to the typical challenge of melanoma prevention. it really is was hoping that the reader will locate this monograph to be of use within the assessment of either preclinical and medical ways to the main concerns that face us in chemoprevention. it's transparent that prevention of melanoma is an concept whose time has come, and the matter now could be to enforce the best ways towards reaching the specified goals.
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Additional info for Control of Growth Factors and Prevention of Cancer
The glucocorticoid effect reaches a maximum only after several days [111. It is reasonable to assume that glucocorticoids function through the regulation of a cellular gene different from B-casein. The induction kinetics and the absence of a glucocorticoid response element (GRE) in the B-casein promoter suggest this mode of action. Prolactin induction of the B-casein promoter in competent, glucocorticoid pretreated cells is rapid and could possibly be mediated by the posttranslational activation of a transcription factor.
Multiple, seemingly unrelated pathways are activated during the course of differentiation. For mammary epithelial cells, for example, it has been shown that cell-cell, cell-matrix and cell-hormone interactions are required to achieve terminally differentiated secretory alveolar cells synthesising milk proteins [4-7]. Neither the signals nor the transduction pathways involved in these multiple interactions have been comprehensively identified. The multitude and the complexity of the regulation in the in vivo situation precludes simple experiments in which individual variables are independently evaluated.
Plenum Press, New York 1987 pp 355-381 Vonderhaar B and Ziska SE: Hormonal regulation of milk protein gene expression. Ann Rev Physiol 1989 (51 ):641-652 Hennighausen L, Westphal C, Sankaran Land Pittius CW: Regulation of expression of genes for milk proteins. In: First N and Haseltine A (eds) Transgenic Animals. Butterworth-Heinemann, Reed Publishing, New York 1991 pp 65-74 Danielson KG, Oborn CJ, Durban EM, Butel JS and Medina D: Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vivo.
Control of Growth Factors and Prevention of Cancer by Michael B. Sporn (auth.), Michael B. Sporn (eds.)