By Rashida A. Karmali JD PhD (auth.), Randall E. Harris MD, PhD (eds.)
The discovery that aspirin and different nonsteroidal anti inflammatory medications (NSAIDs) have amazing antineoplastic houses has revolutionized melanoma examine. In COX-2 Blockade in melanoma Prevention and remedy, a panel of top specialists chronicles the proof for the chemopreventive and healing results of cyclooxygenase-2 (COX-2) inhibitors opposed to nearly all different types of melanoma and provides fascinating new possibilities for using COX-2 blockade of their prevention and therapy. those hugely skilled authors elucidate the method in which COX-2 inhibitors interrupt prostaglandin biosynthesis and melanoma improvement, study the confident epidemiological results of such NSAIDs as aspirin and ibuprofen on a variety of cancers, and display via animal types that NSAIDs inhibit quite a few malignant neoplasms in vivo. additionally they current genetic types confirming the serious position of COX-2 in carcinogenesis and speak about how its molecular biology modulates carcinogenesis through such strategies as mutagenesis, mobile department, angiogenesis, mobilephone differentiation, and apoptosis. additionally, the authors assessment the scientific purposes of chosen NSAIDs which are instantly correct to melanoma prevention and keep an eye on and description the longer term clients of COX-2 blockading agents.
entire and updated, COX-2 Blockade in melanoma Prevention and remedy demonstrates how COX-2 inhibitors and different NSAIDs lessen the chance of cancer and offers melanoma investigators this present day with a transparent and authoritative advisor to the advance of novel brokers with major antineoplastic properties.
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Extra resources for COX-2 Blockade in Cancer Prevention and Therapy
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COX-2 Blockade in Cancer Prevention and Therapy by Rashida A. Karmali JD PhD (auth.), Randall E. Harris MD, PhD (eds.)