By Prof. Dr. Dres. h.c. Harald zur Hausen (auth.)
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Additional resources for Current Cancer Research 1995
A genetic basis for cancer is now firmly established and includes the discovery of proto-oncogenes, whose activation or altered expression promote cell division, and tumor suppressor genes, whose inactivation or loss disrupt the process of normal differentiation and subsequent death and endow the cell with a proliferative advantage. 16 Wild-type fruit fly (Drosophila) larva (above) and a giant larva containing a defective tumor suppressor gene - the first to be genetically Identified and cloned toma syndrome involving defects at a single genetic locus on chromosome 13q).
Based on the number of mutant alleles recovered for each gene, it is possible to estimate the total number of tumor suppressor genes to be more than 100. These findings indicate that numerous genes may prevent cell overproliferation during the development of Drosophila. One of the major efforts of our group is to molecularly isolate these genes in collaboration with other European groups organized in an EC-network. Oho31, a new tumor suppressor gene involved in nuclear cytoplasmic interaction From the collection of P-element induced mutations, we have successfully cloned the oh031 (overgrown hematopoietic organs at chromosomal position 31 A) gene.
These regulatory elements receive specific signals from the inside and the outside of the cell and pass them on to the RNA polymerase. The Signal then initiates or suppresses the activity of the particular gene. The regulatory sequences within the promoter region function by binding specific proteins called "transcription factors". , suppressed, by the respective promoter. A vast array of regulatory sequences and transcription factors exists in the cell. Different combinations and arrangements of individual DNA elements identified by different transcription factors ultimately result in a chronologically coordinated, individual transcription program for each gene.
Current Cancer Research 1995 by Prof. Dr. Dres. h.c. Harald zur Hausen (auth.)