By Prof. Dr. Dr. h.c.mult. Harald zur Hausen (auth.)
From the contents: - Carcinogenicity and Differentiation - Tumor telephone legislation - melanoma hazard elements and melanoma Prevention - Diagnostic and Experimental treatment - Radiological Diagnostic and treatment - utilized Tumor Virology - Tumor Immunology - Genom study and Bio-information
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Additional info for Current Cancer Research 1998
Protein phosphorylation is also the means by which the genes are regulated. lndeed, the adjustment of the gene activity, and hence protein synthesis, to suit external circumstances plays a central role in the behavior of cells. The regulatory proteins that are necessary for this, for example the transcription factors, are components of the cognitive network of the cell. The regulation of their function - among other things by phosphorylation -, how this regulation is influenced by carcinogenic factors, and the consequences of this for the cell are all being studied in detail using the example of the transcription factor AP1.
Clear differences were observed in the time course of the reactions: depending on the substance, the release of mediators either occurred quickly, delayed or late. A quick arachidonic acid response was not always coupled with a quick interleukin1a. response. Those substances that produced a quick cell response were not always the most effective irritants. Therefore, it was important to measure the release of mediators over a Ionger time period in order to be certain of detecting the irritating effect of a chemical.
We have shown that conjugates of several cytotoxic agents with glutathione or glucuronate are substrates for MRP1 mediated transport across the plasma membrane of human tumor cells. An additional substrate of MRP1 is glutathione disulfide (GSSG) which is particularly formed under conditions of oxidative stress when GSSG must be transported into the extracellular space. Thus, MRP1 had been discovered and cloned as a membrane protein associated with multidrug resistance; however, only the elucidation of its function and substrate specificity has led to the molecular identification of the ATP dapendent transport protein for glutathione conjugates and glucuronides.
Current Cancer Research 1998 by Prof. Dr. Dr. h.c.mult. Harald zur Hausen (auth.)