Download PDF by Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D.: Current Topics in Innate Immunity

By Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D. Lambris (eds.)

ISBN-10: 038771765X

ISBN-13: 9780387717654

ISBN-10: 0387717676

ISBN-13: 9780387717678

Innate Immunity has lengthy been considered as the non-specific arm of immune reaction, appearing instantly and in a standard method, to shield the host from infections. within the put up genomic period, our wisdom of the innate immune method is enriched by way of findings at the specificity of innate immune reactions in addition to to novel services that don't strictly correlate with immunological safety and surveillance, immune modulation or irritation. a number of reports point out that molecules interested by innate immunity exert services which are both extra advanced than formerly concept, or pass way past the innate immune personality of the system.

The introduction of high-throughput systems for genome and proteome-wide profiling, including the big quantity of uncooked genetic details that has collected within the databases, have stirred new expectancies in biomedical learn. they've got led scientists to revisit verified organic structures from an international and integrative standpoint. Innate Immunity learn is now confronted with the problem of attempting to combine remoted biochemical pathways into complicated gene and protein regulatory circuits. during this recognize, scientists from worldwide convened on the 4th foreign convention on Innate Immunity (June four - nine, 2006), in Corfu, Greece to debate fresh advances during this quick evolving field.

This quantity represents a set of themes on normal killer cells, mast cells, phagocytes, toll like receptors, supplement, host security in vegetation and invertebrates, evasion recommendations of microorganisms, pathophysiology, protein buildings, layout of therapeutics, and experimental ways mentioned through the conference.

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273(20), 12203-9. Cerwenka, A. and Lanier, L. L. (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol. 1(1), 41-9. Chace, J. , Hooker, N. , Mildenstein, K. , Krieg, A. M. and Cowdery, J. S. (1997) Bacterial DNAinduced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol. 84(2), 185-93. , Gauchat, J. , Thieblemont, N. and Delneste, Y. (2004) Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production.

Bowie, A. G. and Haga, I. R. (2005) The role of Toll-like receptors in the host response to viruses. Mol Immunol. 42(8), 859-67. , Bodmer, J. , French, L. and Tschopp, J. (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem. 273(20), 12203-9. Cerwenka, A. and Lanier, L. L. (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol. 1(1), 41-9. Chace, J. , Hooker, N. , Mildenstein, K. , Krieg, A. M. and Cowdery, J. S. (1997) Bacterial DNAinduced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12.

TLR3-L Ag CCR7 TLR3 NKp30-L iDC NKp30-L TLR3 DC-SIGN QuickTime™ e un decompressore sono necessari per visualizzare quest'immagine. iDC HLA-E MHC-II DC-SIGN Ag mDC CD80 MHC-I HLA-E L Y M P H CD86 TLR3 NK NKp30 CYTOKINE RELEASE NKp30 TLR3 TLR3 NK NKG2A NKG2A NK CD69 CD25 KILLING NKG2A DEACTIVATED NK-CELLS TLR4 TLR4 NKp30 CCR7 NKp30-L iDC DC-SIGN HLA-E NKp30-L iDC DC-SIGN HLA-E TLR3 CD83 NKp30 NK CD69 CD25 NKG2A IL18-induced MIGRATORY PHENOTYPE RECRUITMENT AND PATHOGEN RECOGNITION ACTIVATION AND EDITING N O D E M I G R A T I O N MIGRATION Fig.

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Current Topics in Innate Immunity by Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D. Lambris (eds.)


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