M. J. Weber (auth.), Prof. Dr. Wolfram H. Knapp, Prof. Dr.'s Current Topics in Tumor Cell Physiology and PDF

By M. J. Weber (auth.), Prof. Dr. Wolfram H. Knapp, Prof. Dr. Karel Vyska (eds.)

ISBN-10: 3540130071

ISBN-13: 9783540130079

ISBN-10: 3662023938

ISBN-13: 9783662023938

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24 for white matter. Results and Discussion The CMG as weIl as 3 FDG were found to be effectively accumulated in normal brain cortex; significantly lower accumulation was observed in white matter (Fig. 5). 6) usually showed two exponnential components. The initial rapid decrease of activity probably reflects mixing of indicator in the blood pool and its equilibration with tissue. This was followed by slow indicator elimination (T~ > 90 min), indicating a high retention of non-metabolizable indicator in the blood.

1970) (Table 2). It is important to analyze the kinetics of glucose transport to understand the mechanism of the enhanced sugar uptake by the transformed cells. In the studies carried out with intact cells, the first evidence of an increased Vmax of 2-deoxy-D-glucose transport by tumor cells was obtained by using a mouse sarcoma virus. 2 from control cells (Hatanaka et al. 1970). Since then, there has been no controversy about the increased Vrnax of D-glucose transport on any of the transformed cells tested.

J. 6), is the time in which the transformed cells was saturated with 3-0-methyl-D-glucose and the non-transformed cell was approaching saturation. 8 demonstrates that the 3-0-methyl-D-glucose uptake in transformed cells was much less inhibited than the uptake of the same sugar by the normal cell with similar amounts of cytochalasin B. 8). Marked differences in cytochalasin B inhibition as described above were maintained between the two celllines over a 10,000 fold concentration range. Therefore, 3-0-methyl-D-glucose "infiltrated" into the transformed cells, but not into the non-transformed control cells, in the presence of cytochalasin B.

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Current Topics in Tumor Cell Physiology and Positron-Emission Tomography by M. J. Weber (auth.), Prof. Dr. Wolfram H. Knapp, Prof. Dr. Karel Vyska (eds.)


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