Download e-book for kindle: Developmental Toxicology by Deborah K. Hansen, Barbara D. Abbott

By Deborah K. Hansen, Barbara D. Abbott

ISBN-10: 1420054376

ISBN-13: 9781420054378

Highlighting most up-to-date advances in genetics and biochemistry, the thoroughly revised Third Edition studies the sector from uncomplicated technology, medical, epidemiological, and regulatory views. Contributions from best opinion leaders within the box assemble advancements in molecular embryology and mobilephone biology as they observe to difficulties in developmental toxicology. It covers checking out of pharmaceutical and environmental brokers and interpretation of developmental toxicology info, highlighting mathematical and statistical ideas, in addition to the consequences of poisonous publicity at the useful improvement of assorted organs.

The dating among maternal and developmental toxicology is tested, as well as present ideas for learning chemical disposition, metabolism, and placental move. shut realization is given to the regulatory elements of checking out and probability evaluate. Pre- and postconceptional medical care and genetic components in scientific developmental toxicology also are discussed.

Key issues include:

  • the roles of apoptosis and sign transduction pathways in basic and irregular development
  • the function of epigenetic alterations in development
  • the function of meals and person susceptibility
  • the application of bioinformatics
  • global and specific gene expression changes

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Example text

65. Simonian PL, Grillot DAM, Merino R, et al. Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J Biol Chem 1996; 271:22764–22772. 66. Kuwana T, Bouchier-Hayes L, Chipuk JE, et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005; 17:525–535. 67. Letai A, Bassik MC, Walensky LD, et al. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

17. Coleman ML, Sahai EA, Yeo M, et al. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK 1. Nat Cell Biol 2001; 3:3339–3345. 18. Liu X, Zou H, Slaughter C, et al. DFF, a heterdimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997; 89:175–184. 19. Soldani C, Scovassi AI. Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: An update. Apoptosis 2002; 7:321–328. 20. Du C, Fang M, Li Y, et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

Ley R, Balmanno K, Hadfield K, et al. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, bim. J Biol Chem 2003; 278:18811–18816. 48. Akiyamma T, Bouillet P, Miyazaki T, et al. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 2003; 22:6653–6664. 49. Puthalakath H, Huang DCS, O’Reilly LA, et al. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.

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Developmental Toxicology by Deborah K. Hansen, Barbara D. Abbott

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