By R. M. Niles (auth.)
The 5th of the once a year learn meetings of the yankee Institute for melanoma examine used to be held September l-2, 1994, on the L'Enfant Plaza inn in Washington, DC. correctly, in view of present instructions in study, the subject matter was once "Diet and melanoma: Molecular Mechanisms of Interactions". This complaints quantity comprises chapters from the platform shows and abstracts from the poster consultation hung on the top of the 1st day. The subtopics for the tl;rree periods held have been "Retinoids, supplementations A and Din melanoma Prevention and Therapy," "Choline and Lipids: sign Transduction, Gene Expression and progress Regulation," and "Dietary elements and law of Oncogenes, progress and Differentiation. " A normal evaluation on supplements A and D emphasised and D, as well as their confirmed roles in imaginative and prescient, replica, and bone mineral homeostasis, may well play major roles in regulating mobile functionality. diet A metabolites, trans-retinoic acid and 9-cis-retinoic acid, keep an eye on progress and differentiation. moreover, nutrition A disadvantaged animals have been extra prone to either spontaneous and carcinogen-induced tumors. Epidemiological reports confirmed a correlation among low A consumption and better incidences of specific sorts of human cancers. Conversely, all-trans retinoic acid turns out to be useful in remedy and keep an eye on of particular types of melanoma. Physiologically, nutrition D is switched over to the energetic shape, l ,25-dihydroxyvitamin D (VD). VD regulates hormone construction and secretion, myocardial contractility, vascu three three three lar tone, and development inhibition and differentiation.
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Additional resources for Diet and Cancer: Molecular Mechanisms of Interactions
Our recent studies show that an HPV16-immortalized cervical cell line, ECE 16-1, displays an enhanced sensitivity to retinoids (28). These cells are more readily growth suppressed by retinoids and regulation of cell differentiation is more retinoid-sensitive compared to normal cells (28,29). Similar results have been noted in HPVimrnortalized epidermal foreskin keratinocytes (30). In the present manuscript we review our work on the retinoid effects on cell differentiation (28,29,31,32,33,34,35,36,37), HPV16 oncogene expression (29) and insulinlike growth factor-!
As shown in Fig. 8, as measured by immunoprecipitation or binding assay, the level ofEGF-R is approximately 2 times higher in ECE16-1 cells compared to normal cervical epithelial cells. Moreover, incubation of ECE16- l cells with 100 nM RA(crosshatched bars) reduced EGF-R levels by approximately 50% compared to untreated (open bars) cultures. The reduction in EGF-R level by RA is concentration-dependent with half-maximal suppression at around 1 nM RA (Fig. 9). This reduction in EGF-R level is correlated with a parallel RA-dependent reduction in proliferation (40)(Fig.
Gouveia J, Hercend T, Lemaigre G et a!. Degree of bronchial metaplasia in heavy smokers and its regression after treatment with a retinoid, Lancet 1:710-12 (1982). Vitamin A Chemoprevention of Lung Cancer 29 30. Lee JS, Lippman SM, Benner SE, Lee JJ, Ro JY, Lukeman JM, Morice RC, Peters EJ, Pang AC, Fritsche HA Jr. Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia, J Clin One 12(5):937-45 (1994). 31. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group.
Diet and Cancer: Molecular Mechanisms of Interactions by R. M. Niles (auth.)