Download PDF by Marvin Stein, Andrew H. Miller (auth.), Herman Friedman,: Drugs of Abuse, Immunity, and AIDS

By Marvin Stein, Andrew H. Miller (auth.), Herman Friedman, Thomas W. Klein, Steven Specter (eds.)

ISBN-10: 1461362970

ISBN-13: 9781461362975

ISBN-10: 1461529808

ISBN-13: 9781461529804

This quantity relies at the application of the second one overseas convention on medicinal drugs of Abuse, Immunity and AIDS, held in Clearwater seashore, FL in June 1992. The convention was once supported partially by means of the collage of South Florida collage of drugs with monetary the help of the nationwide Institute on Drug Abuse. the focal point of this convention used to be the results of substances of abuse on immunity. it truly is now widely known that psychoactive medicinal drugs of abuse, together with marijuana, cocaine, and opiates, in addition to alcohol, have marked results in anyone, together with results on their anxious process and behaviour. long ago twenty years, the scope of reports about the results of a few medicinal drugs of abuse have additionally concerned investigations of adjustments of varied physiologic parameters together with results at the immune method. and the impression of such immune adjustments on common physiological responses. during this regard, contributors during this moment foreign convention supplied more moderen info bearing on either uncomplicated and medical elements of substances of abuse and immunity, particularly immunodeficiencies. during this regard, advances were made in recent times about the nature and mechanisms wherein the immune approach is regulated and the potential mechanisms in which medicinal drugs of abuse effect such immune platforms. specifically, the emergence of psychoneuroimmunology as a brand new self-discipline the decade has heightened curiosity within the immune responses motivated by means of psychoactive medicinal drugs. This has ended in interdisciplinary investigations related to either scientific and simple scientists, together with microbiologists, immunologists, physiologists, psychiatrists, oncologists, psychologists, etc.

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J. McDonough, J. J. Madden, A. Falek, D. A. Shafer, M. Pline, D. Gordon, P. Bokos, J. C. Kuehnle, and J. Mendelson, Alteration of T and nulllmphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence of opiate receptor sites on T-Iymphocytes, I. Immunol. 124: 2539 (1980). 11. J. Wybran, T. Appelboom, J. P. Famaey, and A. Goverts, Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T -lymphocytes. J. Immunol. 123:1068 (1979).

Kaslow, W. C. Blackwelder, D. G. Ostrow, D. Yerg, J. Palenicek, A. H. Coulson, and R. O. MA. 261:3424 (1989). 19. K. M. Farizo, J. Buehler, M. E. Chamberland, B. M. Whyte, E. S. Froelicher, S. G. Hopkins, C. Reed, E. D. Makotoff, D. L. Cohn, S. Troxler, A. F. Phelps, and R. L. MA. 267:1798 (1992). 20. J. M. Zenilman, B. Erickson, R. Fox, C. A. Reichart, and E. W. Hook, III. MA. 267:843 (1992). 21. MA. 263:371 (1990). 22. P. N. Fultz, A. M. McClure, D. C. Anderson, R. B. Swenson, R. Anand, and A.

Had the opportunity existed in this study to examine different sampling regimens and conditions of opiate-withdrawal, and multiple instances of opiate-withdrawal, it is possible that the phenomenon of viral induction consequent to opiate-withdrawal would have been demonstrated more robustly. Given the relationship of stress to withdrawal and viral induction as discussed previously, such a possibility is, in fact, quite probable. Because of what is known about the relationship of the expression of immunodeficiency viruses to the onset of AIDS and because opiate-withdrawal is a common and chronic occurrence for most street heroin addicts, such possibilities have very serious public-health implications.

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Drugs of Abuse, Immunity, and AIDS by Marvin Stein, Andrew H. Miller (auth.), Herman Friedman, Thomas W. Klein, Steven Specter (eds.)


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