By Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher (auth.), Gabor M. Rubanyi M.D., Ph.D. (eds.)
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Dis. 127: 301, 1983. 30 ENDOTHELIN 9. HOLDEN, W. , and E. McCALL. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium. Exp. Lung Res. 7: 101-112, 1984. 10. HoM, G. , R. F. HIGHSMITH, and D. C. PANG. In vivo hemodynamic effects of endotheliumderived constricting factor in the dog. Drug Dev. Res. 18: 145-151, 1989. 11. O'BRIEN, R. , and I. F. McMURTRY. Endothelial cell supernates contract bovine pulmonary artery rings. Am. Rev. Respir. Dis. 129: 337, 1984.
Am. J. Physiol. 248 (Cell Physiol. 17): C550-C556, 1985. 7. HIGHSMITH, R. , D. C. PANG, and R. M. RAPOPORT. Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. J. Cardiovasc. Pharmacal. 13: S36-S44, 1989. 8. HOLDEN, W. , and E. McCALL. Hypoxic vasoconstriction of porcine pulmonary artery strips in vitro requires an intact endothelium. Am. Rev. Respir. Dis. 127: 301, 1983. 30 ENDOTHELIN 9. HOLDEN, W. , and E. McCALL. Hypoxia-induced contractions of porcine pulmonary artery strips depend on intact endothelium.
Responses were compared with those from untreated controls, and no significant differences were apparent. Effectiveness of antagonists was confirmed by noting that the responses to their respective agonists were abolished. 5 kd. CONFIRMATORY EVIDENCE Independent confirmation of most of the above properties of EDCF was obtained in 1986 and 1987 by Drs. Gillespie and Owasoyo at the University of Kentucky and by Drs. O'Brien, Robbins, and McMurtry of the University of Colorado. 5 reported in 1986 that inhibition of cyclooxygenase or lipoxygenase had no effect on EDCF-induced increases in coronary perfusion pressure, thereby excluding a role for metabolites of arachidonate.
Endothelin by Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher (auth.), Gabor M. Rubanyi M.D., Ph.D. (eds.)