By C. Lauritzen (auth.), Professor Dr. med.vet.habil. Michael Oettel, Dr. rer.nat. Ekkehard Schillinger (eds.)
For decades, Springer has been publishing a magnificent sequence of textbooks of pharmacology that have set criteria in scientific technological know-how. unusually, an in depth assessment of the present state-of-the-art in examine on estrogens and anti estrogens was once nonetheless missing. the current volumes on estrogens and antiestrogens offer a entire evaluation of a box of study during which extraordinary growth has been remodeled the prior few years. New insights into the mechanisms of steroid hormone motion ended in a big variety of courses from which new rules of preventive and healing appli cations of estrogens and antiestrogens emerged. even though quite a few digital information bases supply easy accessibility to this copious details, there has been a transparent necessity for a monograph-style textbook which assesses and summarizes present wisdom during this speedily increasing box of study. it's going to be famous, notwithstanding, that, because of this dynamic improvement, it's slightly attainable to comprehensively replace each point of easy and medical wisdom on estro gens and antiestrogens. hence, the goal of the editors used to be to supply the reader with an summary of the "classic" and such a lot lately explored components of study and stimulate destiny pursuits in uncomplicated and utilized endocrinology. Estrogens have been one of the first steroid hormones defined within the clinical literature. for the reason that they have been first remoted, because the chemical, synthesic and pharmacological characterization of evidently taking place estrogens and, afterward, of orally energetic derivatives, estrogen examine has produced continu ously hallmark ends up in reproductive endocrinology worldwide.
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Additional info for Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens
II. ) and estrogens as antifertility hormones. Contraception 31:1-7 Simmer HH (1971b) Josef Halban (1870-1937). Pionier der Endokrinologie der Fortpfianzung. Wien Klin Wschr 121:549-555 Simmer HH (1980) Die Entdeckung des Ostriols. Endokrinologie-Informationen. Demeter Verlag, Grafelfing, 4:252-262 Simmer HH (1986) Gynakologische Endokrinologie in den Verhandlungen der Deutschen Gesellschaft fUr Gynakologie von 1886 bis 1935. Beitrage deutschsprachiger Frauenarzte. In: Beck L (Hrsg) Zur Geschichte der Gynakologie und Geburtshilfe.
Am J Obstet Gynecol 31:316-321 Papanicolaou GN (1948b) The sexual cycle in the human female as revealed by vaginal smears. Amer J Anat 52:519-523 Paulsen AC (1965) (ed) Estrogen Assay in Clincal Medicine. University of Washington. Press Seattle/Wa Philipp E (1942) Wie entstehen die Hormone der Plazenta? Geburtsh Frauenheilk 4:433--437 Plotz EJ (1957) Die Anwendung radioaktiver Isotope in der Erforschung des Ostrogenstoffwechsels. Geburtsh Frauenheilk 17:595-599 Ratschow M (1944) Die Sexualhormone als Heilmittel innerer Krankheiten.
1992). Scheme 5 - MeO F:09=>° (OH)'B~O I MeO ~ MeO IA 32 31 2, estrone .. K HOx;cJ" 33 + ~ili HOYJ F 34 Due to electronic and steric reasons, carbon atom C-1 is far less accessible to substitution by commonly used procedures. , NH 2 ) in order to enable C-1 attack. After subsequent removal of the auxiliary C-4 substituent, C-1-halogenated estrogens are obtained (HYLARIDES et al. 1984) as shown in Scheme6. Nucleophilic aromatic substitution of estrogens is possible when the aromatic ring is complexed to a transition metal.
Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens by C. Lauritzen (auth.), Professor Dr. med.vet.habil. Michael Oettel, Dr. rer.nat. Ekkehard Schillinger (eds.)