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By Ross Pinkerton, A. G. Shankar, Katherine Matthay

ISBN-10: 0470659645

ISBN-13: 9780470659649

This booklet is up to date with proof from the most recent released experiences and is extra clinically concentrated, with an emphasis on software of the trial findings. With elevated insurance of trials within the quarter of supportive take care of pediatric melanoma sufferers, every one bankruptcy opens with a medical query and concludes with a precis at the trial findings from knowledgeable commentator.

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14 Anninga JK, Gelderblom H, Fiocco M et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand? Eur J Cancer. 2011;47(16):2431–45. 15 Meyers P, Gorlick R, Heller G et al. Intensification of ­pre-operative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol. J Clin Oncol 1998;16:2452–8. 16 Jaffe N, Robertson R, Ayala A et al. Comparison of intraarterial cis-diamminedi-chloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma.

The largest international, collaborative, multi-institutional randomized clinical trial in osteosarcoma to date, EURAMOS 1, has just finished 15 Part 1: Solid tumors recruiting a sufficiently large cohort of patients to address this question. All patients registered received a standard induction regimen consisting of two cycles of AP and four cycles of high-dose methotrexate, before proceeding to surgical resection. Postoperative therapy was determined by histological response of the tumor. Good responders were randomized between MAP and MAP + pegylated interferon-α2b; poor responders were randomized to continue MAP or to receive MAP plus ifosfamide and etoposide.

12 Winkler K, Beron G, Delling G et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 1988;6:329–37. 13 Bacci G, Picci P, Ruggieri P et al. Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. Cancer 1990;65:2539–53. 14 Anninga JK, Gelderblom H, Fiocco M et al. Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?

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Evidence-Based Pediatric Oncology by Ross Pinkerton, A. G. Shankar, Katherine Matthay


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