By S. Vynckier, R. Schmidt (auth.), Prof. Dr. Rita Engenhart-Cabillic, Prof. Dr. André Wambersie (eds.)
Fast neutron remedy was once brought in London in 1970. The booklet offers an outline of the advancements of the earlier 28 years, assesses the result of speedy neutron therapy, and reports the compiled scientific information all over the world. The authors describe the radiobiological profile of the neutron beams and evaluation the neutron RBE for secondary melanoma induction, they introduce heavy-ion remedy, which mixes excessive actual selectivity with the organic benefits of high-LET radiation for a few tumor varieties, and eventually they describe the very fresh advancements in Boron Neutron trap treatment (BNCT).
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Extra resources for Fast Neutrons and High-LET Particles in Cancer Therapy
For lung and air cavities the effect can be taken into account by use of the effective attenuation method. Besides this transmission calculation, a Kerma correction needs to be applied to take into account the difference in atomic composition of soft tissue and the heterogeneity. The proton contents of the organs are essential for the energy transferred to the tissue. As the atomic composition in a transverse slice of a patient is not known, additional information may be given by classifying the visible organs so that the Kerma correction can be taken from a table or by directly converting Hounsfield data into Kerma corrections (Schmidt and Thorn 1990).
Therefore the reported doses at the ICRU reference point should include the total dose (neutron+photon) and the photon dose. Outside the neutron beam the relation between neutron and photon dose changes so that a decrease in RBE occurs. Therefore in a three-dimensional treatment plan with neutrons the photon dose at the organs at risk should also be given. As the absorbed dose in a patient depends on the proton contents, the proton contents at the ICRU reference point should be representative of the planning target volume (PTV).
Moreover, the radiobiological characteristics of the neutron beam should be determined under reference conditions in order to allow comparisons to be made. However, in order to be on the same level of precision, more problems need to be solved: - The generation of these neutron beams is more complicated and will besides the standard quality control procedures need some supplementary quality verifications. - In vivo dosimetry is well established in photon therapy. Different detectors (i. e. TLD) (Loncol et al.
Fast Neutrons and High-LET Particles in Cancer Therapy by S. Vynckier, R. Schmidt (auth.), Prof. Dr. Rita Engenhart-Cabillic, Prof. Dr. André Wambersie (eds.)