By Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)
These 4 volumes comprising "GnRH Analogues in melanoma and Human replica" are a distillation of the shows of the invited audio system at a landmark overseas Symposium bearing an analogous identify, geared up through considered one of us (B. L. ) and held in Geneva, Switzerland in February 1988. The Symposium used to be actually interdisciplinary spanning gonadal hormone established sickness together with numerous different types of melanoma and varying to regulate of fertility, either professional- and notion. The foreign style may be stuck from the 480 contributors and 259 participants drawn from 14 international locations. The Symposium, and as a result this ebook, wouldn't have been attainable with out the backing of The overseas Committee for learn in replica and the sponsorship of the foreign Society of Gynecologic Endocrinology, The Swiss Society of Fertility and Sterility, The collage of Geneva institution of medication, The Swiss Society of Endocrinology and the united states starting place for reviews in replica Inc. , and aid from the realm overall healthiness association. B. H. Vickery B. Lunenfeld June 1989 record OF individuals TO THE sequence H. Bartermann A. Abbondante First Institute of Obstetrics and Urologische Universitatsklinik Kiel Gynecology Arnold-Heller Strasse 7 collage "La Sapienza" D-2300 Kiel 1, FRG Rome,ltaly M. Bartholomew P. Abel division of Medicine/Endocrinology division of Urology Milton S. Hershey scientific middle Hammersmith health center Pennsylvania kingdom college DuCane street PO field 850, Hershey, PA 17033, united states London W12 OHS, united kingdom D. Beck H.
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Extra info for GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues
Testicular luteinizing hormone receptor content and in vitro stimulation of cyclic adenosine 3',5'-monophosphate and steroid production: a comparison between man and rat. J Clin Endocrinol Metab, 55, 882 17. Pahnke, VG, Leidenberger, FA and Kunzig, HJ (1975). Correlation between hCG (LH)-binding capacity Leydig cell number and secretory activity of rat testis throughout pubescence. Acta Endocrinol (Copenh) 79, 610 18. Paz, GF, Winter, JSD, Reyes, FI and Faiman, C (1980). Developmental pattern of testosterone production by the rat testis.
In hypogonadotrophic hypogonadism, , Leydig cell activation is absent. In precocious puberty, therapy is based on the hypothesis that prepubertal hypogonadism does not damage the quiescent germinal epithelium. This is confirmed by successful induction of fertility in men after long duration of "idiopathic" hypogonadotropic hypogonadism of hypothalamic origin. In the rat, daily short-lasting LH release can cause progressive Leydig cell hyperplasia similar to human hypergonadotrophic hypodonadism.
Safety parameters for the effect of buserelin treatment on non-reproductive organ systems included adrenal function (ACTH content of the adenophypophysis, adrenal weight and corticosterone content), and thyroid function (thyroid weight, hypothalamic TRH content). EFFECTS OF BUSERELIN TREATMENT BEGUN PREPUBERTALLY Body weight development was slightly retarded in rats treated with buserelin for 8 weeks (Table 1). The treatment inhibited weight gain of the reproductive organs. The normal pubertal weight increase of reproductive organs (post-pubertal weight of testes, seminal vesicles and prostate) was completed by 8 weeks after stopping treatment in rats treated for 8 weeks, but not in rats treated with busere1in for 16 weeks and recovering for 8 weeks.
GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues by Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)