By Charles I Berlin, Richard P. Bobbin
This can be the 6th publication within the Kresge - Mirmelstein Award sequence. each one ebook within the sequence is made out of the complaints from this annual symposium held to honor the paintings of a superb auditory scientist. This quantity honors the paintings of Dr. David Corey for his discoveries on hair cellphone micromechanics. different individuals contain prime auditory scientists and symbolize a synthesis of the most recent details and pondering on hair cells and their auditory functionality.
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Extra resources for Hair Cell Micromechanics & Hearing (Singular Audiology Text.)
P. (1991). Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7, 985–994. Avraham, K. , Steel, K. , Kingsley, D. , Russell, L. , Mooseker, M. , Copeland, N. , & Jenkins, N. A. (1995). The mouse Snell’s waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nature Genetics 11, 369–375. Benser, M. , Marquis R. , & Hudspeth A. J. (1996). Rapid, active hair bundle movements in hair cells from the bullfrog’s sacculus.
1998). , 1998). Regardless of the mechanism, it seems likely that the fast component of adaptation is associated with a negative feedback force on the bundle, and that this may lead to mechanical ringing of the bundle. Because the bundle puts energy into the ringing, it can amplify the vibration of a sinusoidal stimulus near the characteristic frequency, and nearby hair cells of the cochlea might act together to amplify the vibration of the basilar membrane. Perhaps the cochlear amplifier is in the transduction channel itself.
An adaptation process has been described which is thought to restore the tip-links to a constant tension regardless of the hair bundle’s steady-state position, in order to extend the dynamic range of the hair bundle while maintaining sensitivity (Eatock, 45 46 HAIR CELLS MICROMECHANICS AND HEARING Corey, and Hudspeth, 1987; Crawford, Evans, and Fettiplace, 1989; Hacohen, Assad, Smith, and Corey, 1989; Assad and Corey, 1992). Recently, it has been shown that adaptation can be extremely fast, and it has been postulated that adaptation may impart a mechanical tuning to hair bundles (Ricci and Fettiplace, 1997; Ricci, Wu, and Fettiplace, 1998).
Hair Cell Micromechanics & Hearing (Singular Audiology Text.) by Charles I Berlin, Richard P. Bobbin