By Z. S. Khachaturian (auth.), Prof. Dr. Francois Boller, F. Forette, Z. S. Khachaturian, Michel Poncet, Yves Christen PH. D. (eds.)
The time period "Alzheimer's affliction" is at the moment used to consult senile and in addition presenile dementia, however the heterogeneity of this affliction is validated in lots of of its elements. this is often of significant theoretical curiosity, and with the looks of latest healing interventions, it will probably additionally begin to have very major functional value. To shed a few mild at the debate, the Fondation Ipsen prepared a global symposium which happened on April 6, 1992. This quantity comprises the court cases of this assembly, which was once attended by means of researchers in epidemiology, scientific neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.
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Additional info for Heterogeneity of Alzheimer’s Disease
The patients with psychotic symptoms showed a significantly more rapid rate of decline in MMSE. Rosen and Zubenko (1991) studied 32 dementia patients with definite, histopathologically confirmed AD. Over a follow-up period of zero to five years, psychosis emerged in 15 (47%) and major depressive episode in seven patients (22%). The occurrence of psychosis at any time during the natural history was associated with more rapid cognitive decline on the MMSE (one-tailed t test), but not with increased mortality.
In a study of 178 patients with probable or possible AD drawn an epidemiologic catchment area, Burns et al. (1990a) reported that the presence of hallucinations at initial visit was associated with greater deterioration in cognitive function over the ensuing 12 months. Delusions and misidentifications, on the other hand, did not predict a faster rate of decline. Teri et al. (1990) studies 106 patients with primary degenerative dementia who were given the Mini-Mental State Examination (MMSE) one to five times over up to three years.
Came to our attention after he reported he was having difficulty calculating. S. Army General had been the president of an engineering firm when he began to experience difficulty in tabulating data, balancing his checkbook, and remembering telephone numbers. He was referred to our research group following a clinical evaluation which determined that he had probable AD. We were able to study G. C. in some detail over the subsequent two years. , 1989). Given that dyscalculia was his initial and outstanding cognitive deficit, we decided that a comprehensive examination and error analysis of G.
Heterogeneity of Alzheimer’s Disease by Z. S. Khachaturian (auth.), Prof. Dr. Francois Boller, F. Forette, Z. S. Khachaturian, Michel Poncet, Yves Christen PH. D. (eds.)