Gordon D. Ross's Immunobiology of the Complement System. An Introduction for PDF

By Gordon D. Ross

ISBN-10: 0125976402

ISBN-13: 9780125976404

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Additional info for Immunobiology of the Complement System. An Introduction for Research and Clinical Medicine

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This inacti­ vation is of the greatest importance in the control of the feedback loop of the alternative pathway (see Chapter 2). It also plays a part in the control of the classical pathway, as once C3 is inactivated, it can no longer bind C5 and hence further production of the membrane attack complex is prevented. The initial cleavage of C3b by factor I can only occur in the presence of a cofactor, and either factor H or CRi can act in this respect 1. The Classical Pathway 41 Fig. 9. A cluster of C2, C3, C4, and C5 molecules bound to the target surface around an activated CT molecule.

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R. D. Campbell, J. Gagnon, and R. R. Porter, Biochem. J. 199, 359-370 (1981). 23. J. W. F. Goers and R. R. Porter, Biochem. J. 175, 675-684 (1978). 24. N. R. Cooper and H. J. Müller-Eberhard, Immunochemistry 5, 155-169 (1968). 25. R. B. Sim, T. M. Twose, D. S. Paterson, and E. Sim, Biochem. J. 193, 115-127 (1981). 26. D. E. Isenman and J. R. Young, J. Immunol. 132, 3019-3027 (1984). 27. M. A. Kerr and J. Gagnon, Biochem. J. 205, 59-67 (1982). 28. W. Opferkuch, H. J. Rapp, H. R. Colten, and T. Borsos, J.

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Immunobiology of the Complement System. An Introduction for Research and Clinical Medicine by Gordon D. Ross


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