By I. Rietbrock (auth.), Prof.Dr. Klaus Peter, Prof.Dr. Burnell R. Brown, Prof.Dr. Eike Martin, Prof.Dr. Olof Norlander (eds.)
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Extra resources for Inhalation Anesthetics: New Aspects 2nd International Symposium
Figure 1 shows the body as a largely parallel arrangement of its organs interconnected by the circulating blood. On the basis of this model and the partition coefficients published by Eger and Lowe [6, 7, 8] Fig. 2 gives the ratio of arterial and venous concentration at constant alveolar concentrations for various tissues. The very long half-life of adipose tissue (curve 4) is responsible for extremely low levels in the venous blood pool of the fatty tissue during wash-in and wash-out. During anesthesia adipose tissue can practically be regarded as an eliminating organ, while after termination of anesthesia adipose tissue leads to an exposure to "endogenous trace amounts" for a prolonged period.
_ ... _ ')( .. _ .. _ ... _ . ' /,... : .. /0 _. ~o. _ . 5 _. - - _.. _... - . /" 'cl' '0 o 20 10 40 30 60 50 I [min] Fig. 7. Measured and theoretical uptake values according to a theoretical model (Fig. 6) during I MAC halothane anesthesia (1 h) with end-tidal control. 8. Measured and calculated anesthesia uptake according to Lowe and Ernst . For explanation see text 40 D. Thomson et al. VHal(ml/min) = Q. Ca/Vf Q = Vo /5 or BW3/4 ·2 Ca = FMAC· "-BIO Arterial concentration is the fraction of MAC times lambda, the blood-gas partition coefficient value taken from the literature.
However, for the actual administration of the dosage, the distribution space of the anesthesia equipment and its saturation must also be taken into account; these can be identified through experiments. 5 MAC respectively in 60% N 2 0. 15%. 5 MAC. 5 MAC. The simple form of dosage causes an overshooting of alveolar concentrations at the end of the induction phase, which makes it possible to maintain the desired alveolar concentration subsequently over aperiod of approximately 100 min by delivering a constant inspiratory Concentration.
Inhalation Anesthetics: New Aspects 2nd International Symposium by I. Rietbrock (auth.), Prof.Dr. Klaus Peter, Prof.Dr. Burnell R. Brown, Prof.Dr. Eike Martin, Prof.Dr. Olof Norlander (eds.)