By J. H. Humphrey (auth.), Sigurd J. Normann, Ernst Sorkin (eds.)
This ebook is the result of a gathering held in Davos, Switzerland, February 7-12, 1982 concentrated totally on mononuclear phagocytes and on normal killer (NK) cells. This IX foreign RES Congress was once attended by means of 489 scientists from 31 nations and there have been 340 medical displays in oral or poster consultation. the basic goal of the Congress was once to compile scientists representing a variety of facets of mononuclear phagocyte biology to study and look at cri~ically the results and mechanisms of macrophage progress regulate in addition to the participatio~ of those cells within the afferent and efferent limbs of the immune reaction. extra subject matters integrated the creation and distribution of mono nuclear phagocytes; the intrinsic and extrinsic legislation of those cells; and the foundation, nature, functionality and legislation of NK cells. the last word aim of the Congress used to be to augment verbal exchange among scientists in quite a few nations and disciplines in order that new learn directives should be outlined with which to discover simple elements of macrophage and NK mobilephone participation within the keep an eye on of melanoma and infection.
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Extra resources for Macrophages and Natural Killer Cells: Regulation and Function
So far as immediate type reactions are concerned, the basic concept is that IgE binds to specific receptors on mast cells, and that cross linking of these activates a series of reactions which lead to extrusion of the mast cell granules. What happens thereafter is fascinating, but essentially in the realm of pharmacology. Why some persons but not others develop such allergies remains a mystery, despite the evidence that those with an "atopic" genetic background make IgE more readily. Progress will depend upon defining the allergens responsible.
45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. S. C. SILVERSTEIN Ehlenberger, A. , J. Exp. Med. 145:357, 1977 • Wright, S. , and Silverstein, S. , J. Cell BioI. 91:255a, 1981. , Griffin, F. M. , and Silverstein, S. , J. Exp. Med. 141:1278, 1975. Griffin, F. M. , and Mullinax, P. , J. Exp. Med. 154:291, 1981. Nichols, B. , J. Exp. Med. 144:906, 1976. Murphy, P. , Simon, P. , and Willoughby, W. , J. Immunol. 124:2498, 1980. Fuller, G. , and Ritchie, D. , Annals of the New York Academy of Sciences, 1981, in press.
Rather, I suggest that some of these receptors may mediate special functions in macrophages at unique anatomical sites or at specific stages of macrophage differentiation. For instance, the C3b receptors on resident mouse macrophages (37), MEMBRANE RECEPTORS 25 or the C3b (38) and C3bi receptors on human monocytes (39) mediate binding but not ingestion of particles coated with the corresponding ligands. C3b receptors on inflammatory (40) or lymphokine treated mouse macrophages (41), and C3b and C3bi receptors on phorbol ester treated human macrophages (39) promote phagocytosis of C3b and C3bi coated particles.
Macrophages and Natural Killer Cells: Regulation and Function by J. H. Humphrey (auth.), Sigurd J. Normann, Ernst Sorkin (eds.)