Read e-book online Metal Compounds in Cancer Therapy PDF

By Simon P. Fricker (auth.), Simon P. Fricker (eds.)

ISBN-10: 9401045453

ISBN-13: 9789401045452

ISBN-10: 9401112525

ISBN-13: 9789401112529

The discovery of the antitumour task of cisplatin in 1965 and its next advent into medical trials in 1971 was once the catalyst for a tremendous foreign study attempt investigating the potential for steel compounds in melanoma treatment. Cisplatin now occupies a huge position within the armamentarium of the oncologist because of its effectiveness within the remedy of testicular melanoma. A moment iteration analogue, carbo­ platin, bargains decreased toxicity including healing job, which provides it a spot within the front-line treatment of genitourinary cancers. those and different successes have inspired the quest for novel metal-based medicines for melanoma remedy. learn has proven that steel compounds have power for task not just as cytotoxic antitumour brokers, but additionally in parts comparable to adjuvant remedy, analysis and immunotherapy. the purpose of this e-book is to check and describe the foremost achievements and advancements bobbing up from this overseas examine attempt. The contributing authors come from labora­ tories all through Europe and the United States and signify the various disci­ plines attribute of this study, comparable to medical examine, pharmacology, tumour biology and inorganic medicinal chemistry.

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And Mansour, V. H. (1969) Platinum compounds: a new class of potent antitumor agents. Nature, 222, 385-6. , Orrenius, S. etal. (1991) Modifications of cell signalling in the cytotoxicity of metals. Pharmacol. , 68, 424-9. References 31 Ruddon, R. W. (1987) Cancer Biology, Oxford University Press, New York and Oxford. , Zorzet, S. etal. (1989) Antitumour properties of dimethylsulphoxide ruthenium(II) complexes in the Lewis Lung carcinoma system. Pharmacol. , 21(5), 617-28. , Mestroni, G. and Alessio, E.

Clin. , 12, 117-25. Harder, H. C. and Rosenberg, B. (1970) Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein synthesis in mammalian cells in vitro. Int. J. Cancer, 6, 207-16. Harrap, K. R. (1985) Preclinical studies identifying carboplatin as a viable cisplatin alternative. Cancer Treat. , 12 (supplement A), 21-33. Harrap, K. , Goddard, P. M. etal. (1988) Drug resistance as a focus for new drug design, in Mechanism of Drug Resistance in Neoplastic Cells (eds P. V. Woolley III and K.

Schwartsmann, G. and Workman, P. (1993) Anticancer drug screening and discovery in the 1990s: a European perspective. Eur. J. Cancer, 29A(1), 3-14. Sen, S. and D'Incalci, M. (1992) Apoptosis. Biochemical events and relevance to cancer chemotherapy. , 307(1), 122-7. Sherman, S. E. and Lippard, S. J. (1987) Structural aspects of platinum anticancer drug interactions with DNA. Chem. , 87,1153-81. , Watanabe, M. etal. (1989) Predictability of in vivo chemosensitivity by in vitro MIT assay with reference to the clonogenic assay.

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Metal Compounds in Cancer Therapy by Simon P. Fricker (auth.), Simon P. Fricker (eds.)

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