By Joseph R. Bertino (auth.), Professor Dr. Bruce N. Cronstein, Professor Dr. Joseph R. Bertino (eds.)
Although miraculous, it sort of feels becoming drug built on the sunrise of the period of rational drug layout and therapeutics, methotrexate, may still stay in universal use for the remedy of such a lot of other forms of health problems. furthermore, methotrexate has thoroughly revolutionized the way drugs is practiced in a few speciality components. First built to regard malignancies, methotrexate is now prevalent to regard gynecological difficulties, inflammatory arthritis, pores and skin ailment and possibly different diseases besides. This paintings is designed to provide a wide evaluate of the background of methotrexate's improvement, its previous use and its present healing makes use of. As mentioned in bankruptcy I, aminopterin and methotrexate have been designed to inhibit mammalian folate metabolism however the proposal of folic acid antag onism was once quickly utilized to the advance of antibacterial and anti parasitic brokers. Trimethoprim and sulfa medicines have been one of the first antibiotics constructed and so they stay particularly worthwhile this day for the deal with ment of quite a few infections.
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J Repro Med 43 (1): 44-52 7 Santillana S, Mariategui J, Mas L, Velarde C, Casanova L, Carracedo C, Valdivia S, Gomez H, Otero J, Rodrigues W, Vallejos C (1995) Comparison of two classification systems for metastatic gestational trophoblastic disease: substratification for high-risk patients. Proc Am Soc Clin Oncol14: A768 8 Hartenbach E, Saltzman A, Carter J, Twiggs L (1995) A novel strategy using G-CSF to support EMAICO for high-risk gestational trophoblastic disease. Gynecol Oncol 56 (1): 105-108, 1995.
With this mode of therapy the overall survival for patients was about 20%. The majority of patients recurred in the lungs at six to nine months after amputation. This pattern of recurrence suggested that micrometastatic disease existed at the time of surgery. The original premise that osteosarcoma was a chemoresistant tumor was disproved by studies conducted in the 1970s which demonstrated that it was sensitive to three chemotherapeutic agents: high dose methotrexate (MTX), doxorubicin, and cisplatin [48).
Pharmacal Therapeutics 48: 45-59 87 Bacci G, Ferrari S, Delepine N, Bertoni F, Picci P, Mercuri M, Bacchini P, Brach del Prever A, Tienghi A, Comandone A et al (1998) Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin. J Clin Oncol 16: 658-663 88 Guo W, Healey JH, Meyers PA, Ladanyi M, Huvos AG, Bertino JR, Gorlick R (1999) Mechanisms of methotrexate resistance in osteosarcoma.
Methotrexate by Joseph R. Bertino (auth.), Professor Dr. Bruce N. Cronstein, Professor Dr. Joseph R. Bertino (eds.)