Read e-book online (NAS Colloquium) The Neurobiology of Pain PDF

By Proceedings of the National Academy of Sciences

ISBN-10: 0309065488

ISBN-13: 9780309065481

ISBN-10: 0309569338

ISBN-13: 9780309569330

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Read Online or Download (NAS Colloquium) The Neurobiology of Pain PDF

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Dastmalchi, S. & Levine, J. D. ( 1996 ) Neuroscience 71 , 265–275 . 11. Tanner, K. D. , Gold, M. S. , Reichling, D. B. & Levine, J. D. ( 1997 ) in Molecular Neurobiology of Pain , ed. Borsook, D. ( Int. Assoc. Study of Pain , Seattle ), Vol. 9 , pp. 79–105 . 12. Cantrell, A. R. , Ma, J. Y. , Scheuer, T. & Catterall, W. A. ( 1996 ) Neuron 16 , 1019–1026 . 13. Cantrell, A. R. , Smith, R. D. , Goldin, A. L , Scheuer, T. & Catterall, W. A. ( 1997 ) J. Neurosci. 17 , 7330–7338 . 14. England, S. , Bevan, S.

23. Villiere, V. & McLachlan, E. M. ( 1996 ) J. Neurophysiol. 76 , 1924–1941 . 24. Arbuckle, J. B. & Docherty, R. J. ( 1995 ) Neurosci. Lett. 185 , 70–73 . 25. Caffrey, J. M. , Eng, D. L. , Black, J. A. , Waxman, S. G. & Kocsis, J. D. ( 1992 ) Brain Res. 592 , 283–297 . 26. Elliott, A. A. & Elliott, J. R. ( 1993 ) J. Physiol. (London) 463 , 39–56 . 27. Ogata, N. & Tatebayashi, H. ( 1993 ) J. Physiol. (London) 466 , 9–37 . 28. Roy, M. L. & Narahashi, T. ( 1992 ) J. Neurosci. 12 , 2104–2111 . 29.

Therefore, we generated antisense ODNs to a unique region of the cloned TTX-resistant Na+ channel, PN3/SNS, and assessed the effects of intrathecal ODN administration on PGE2-induced hyperalgesia ( 66 ). Our results indicated that antisense, but not control, ODN sequences produced a small but significant increase in baseline threshold to mechanical nociceptive stimuli, suggesting that activity in a TTX-resistant current contributes to the determination of mechanical threshold. More importantly, antisense, but not control ODN sequences, resulted in a significant reduction in PGE2-induced hyperalgesia.

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