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Extra resources for (NAS Colloquium) The Neurobiology of Pain
Dastmalchi, S. & Levine, J. D. ( 1996 ) Neuroscience 71 , 265–275 . 11. Tanner, K. D. , Gold, M. S. , Reichling, D. B. & Levine, J. D. ( 1997 ) in Molecular Neurobiology of Pain , ed. Borsook, D. ( Int. Assoc. Study of Pain , Seattle ), Vol. 9 , pp. 79–105 . 12. Cantrell, A. R. , Ma, J. Y. , Scheuer, T. & Catterall, W. A. ( 1996 ) Neuron 16 , 1019–1026 . 13. Cantrell, A. R. , Smith, R. D. , Goldin, A. L , Scheuer, T. & Catterall, W. A. ( 1997 ) J. Neurosci. 17 , 7330–7338 . 14. England, S. , Bevan, S.
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Therefore, we generated antisense ODNs to a unique region of the cloned TTX-resistant Na+ channel, PN3/SNS, and assessed the effects of intrathecal ODN administration on PGE2-induced hyperalgesia ( 66 ). Our results indicated that antisense, but not control, ODN sequences produced a small but significant increase in baseline threshold to mechanical nociceptive stimuli, suggesting that activity in a TTX-resistant current contributes to the determination of mechanical threshold. More importantly, antisense, but not control ODN sequences, resulted in a significant reduction in PGE2-induced hyperalgesia.
(NAS Colloquium) The Neurobiology of Pain by Proceedings of the National Academy of Sciences