By Peter Rolfe
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Additional info for Neonatal Physiological Measurements. Proceedings of the Second International Conference on Fetal and Neonatal Physiological Measurements
060 •Calculated for comparison with1 other published results. tIncludes 'classic' and 'atypical patients some of whom started a low phenylalanine diet before the test was done. Figures in brackets are number of subjects for whom values were available. 58 Tetrahydrobiopterin deficiency in the neonate: detection, origin and timing deficiency, either because of malnutrition or because of a genetic defect in folate metabolism, also results in mental retardation (6) without hyperphenylalaninaemia. Leeming et al (4) have reported that 5-methyltetrahydrofolate and vitamin B 1 2 enhance BH4 biosynthesis in an in vitro assay system using rat brain preparations.
Examination of the graphs obtained by plotting these factors against each other showed that, despite clustering of parameters representing shortand long-term variability, they formed a continuum, each measuring a slightly different aspect of the variability present. This may be the reason that no one or two measures of variability can be used to replace all 12 for the prediction of clinical parameters. Although this system of data collection and analysis permitted accurate prediction of clinical course and outcome, it suffered from the major disadvantage that the E C G had to be recorded on magnetic tape and analysis performed at a later date, with the result that information derived could not be immediately available to aid clinical decision-making.
1 kg. W e performed serial studies, making three to five sets of measurements during the first 6 weeks of life in nine premature infants. W e compared the values obtained for blood velocities in the ascending aorta, the descending aorta and the main pulmonary artery. In addition we compared two consecutive studies in those subjects in whom measurements were repeated within a week, to assess the repeatability of the results. Results Satisfactory Doppler signals were obtained in all cases, except for one infant weighing 700 g in whom a pulmonary arterial signal was not found in three successive studies.
Neonatal Physiological Measurements. Proceedings of the Second International Conference on Fetal and Neonatal Physiological Measurements by Peter Rolfe