By Jorge A Lazareff
Neural Tube Defects are a bunch of comparable yet person pathologies which are the commonest congenital anomalies of the critical frightened approach. the significance of this has generated a wide physique of literature that seldom was once written for the clinician in a complete and didactic demeanour. during this publication, every one bankruptcy is richly illustrated and devoted to one illness with subheadings that surround etiology, molecular biology, medical anatomy, indicators, motive for surgeries, common background and transition into maturity. This systematic content material scheme permits the treating medical professional to simply entry info that may support him/her comprehend the patient's situation and choose the simplest therapy choices.
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Extra resources for Neural Tube Defects
4. FP3 and NOT1 FP3 and NOT1 are markers for glia and neuronal cell bodies of distal spinal cord. These markers are totally absent in MMCL placode, indicating the paucity of cell bodies in the placode. FP3 and NOT1 are markers for glia and neuronal cell bodies of distal spinal cord. Inference from histochemical study of myelomeningocele placode • Alterations of dorsoventral patterning and rostrocaudal patterning in the placode. • Distortion of cord with relative sparing of the ventral elements.
The lateral most border of the neural placode has transitional epithelium and is at times highly vascular when it is called medullovasculosa, similar to cerebrovasculosa of anencephaly. 29 September 20, 2010 30 16:4 spi-b864 9in x 6in b864-ch04 Neural Tube Defects The placode (P), the central canal (C) and the medullovasculosa (Mv) are depicted in the picture below. The central groove within the neural placode represents the central canal, wtih the ventral roots exiting medially and the dorsal roots exiting laterally, as it would from the posterior surface of the placode.
2. 3. 4. Dorsal enteric fistula Neurenteric cyst Diastematomyelia (split cord malformation) Dermal sinus II. Anomalies of Primary Neurulation 1. Myelomeningocele 2. Lipomyelomeningocele 3. Meningocele III. Combined Anomalies of Gastrulation and Primary Neurulation 1. Hemimyelomeningocele IV. Anomalies of Differentiation Secondary 1. Thick filum terminal 2. Terminal myelocystocele Neurulation and Retrogressive September 20, 2010 16:4 spi-b864 9in x 6in Part I Spinal Defects 27 b864-ch04 This page is intentionally left blank September 20, 2010 16:4 spi-b864 9in x 6in b864-ch04 Chapter 4 Myelomeningocele Introduction Myelomeningocele (MMCL) is the most common form of NTD and is also known as spina bifida cystica.
Neural Tube Defects by Jorge A Lazareff