Download PDF by I. T. Magrath (auth.), Ian Magrath (eds.): New Directions in Cancer Treatment

By I. T. Magrath (auth.), Ian Magrath (eds.)

ISBN-10: 3540190635

ISBN-13: 9783540190639

ISBN-10: 3642834051

ISBN-13: 9783642834059

During the previous few many years, there was a major development within the remedy of melanoma. there's facts that this pattern is constant, in response to the achievements re­ sulting from the mixed efforts of clinicians and uncomplicated re­ seek employees. This e-book is an instance of such interplay and collaboration. It used to be ready through authors representing either components of labor. lots of the paintings mentioned during this e-book isn't really in simple terms theoretical, yet has been experimentally effectively demonstrated and occasionally utilized clinically. This paintings has, although, now not but been generalized and practiced on a large scale. a number of the effects stated right here relate to new facets and open new horizons for destiny development. This ebook could be of significant worth for either clinicians and uncomplicated learn staff. VICC remedy and Rehabilitation Programme ISMAIL ELSEBAI Chairman Preface the 3 major ways to the therapy of melanoma are surgical procedure, radiotherapy, and chemotherapy. at the present time, all malignant neoplasms are controlled by way of a number of of those modalities, with various luck charges reckoning on the kind of tumor, its measure of unfold, and the knowl­ aspect and talent with which the remedy plan has been designed and performed. within the usa and in Europe, approximate­ ly half all melanoma is almost immediately curable, yet this has been the case for about 20 years.

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Moderate to severe gastrointestinal and peripheral nerve toxicity limited the frequency and duration of administration of metronidazole. Further in vitro and in vivo work established that the 2-nitroimidazoles were superior to the 5-nitro compounds as hypoxic cell sensitizers based on a higher electron affinity and lipophilicity [34, 35]. Misonidazole (Ro-07-0582) was selected for clinical use and has undergone extensive phase I to III testing by the Radiation Therapy Oncology Group (RTOG) and others [36].

In addition to considering the probability of incurring a major complication, the probability of treating it effectively is an integral part of the initial treatment decision. Thus, if a radiation complication is manageable, the higher dose (program B) should be used to maximize tumor control and the higher complication rate be accepted. While it is felt that the tolerance of normal tissues and "resistant" tumor cell populations have limited the radiocurability of certain tumors, especially at higher clinical stages, research in radiobiology and radiation physics is providing ways of increasing cure while limiting morbidity _It is the intent of this chapter to review the state-of-the-art information on several innovative approaches in radiation oncology and to speculate on areas of future research_ Topics included in this review are radiobiology and tumor biology, radiation sensitizers and protectors, combined modality therapy, systemic use of radiation, and particle beam radiation therapy.

High-dose therapy is sometimes carried out in conjunction with "marrow rescue," whereby autologous marrow, stored (cryopreserved) prior to the administration of the high-dose drug therapy, or allogeneic bone marrow is 14 reinfused into the patient to permit marrow recovery after what is believed to be a lethal dose of drug (with or without total body irradiation) has been administered. Marrow rescue is logical where myelosuppression is the major form of toxicity of the drug in question. , liver toxicity with the nitrosoureas, cerebellar toxicity with high-dose ara-C, and the potential for cardiac toxicity with very high-dose cyclophosphamide.

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New Directions in Cancer Treatment by I. T. Magrath (auth.), Ian Magrath (eds.)


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