By Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen
With the advances of immunohistochemistry together with confocal microscopy, airway sensory receptor end-organs can now be tested and evaluated objectively. in accordance with their ‘neurochemical coding’, morphology, position and starting place, 3 sensory receptor finish organs are at the moment morphologically well-characterised: soft muscle-associated airway receptors (SMARs), neuroepithelial our bodies (NEBs) and visceral pleura receptors (VPRs). the current details at the practical morphological and neurochemical features of those sensory receptors, results in vital conclusions approximately their (possible) functionality.
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Additional resources for Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors
1999). Smooth Muscle-Associated Airway Receptors 29 Fig. 4 Neurochemical characterisation of rodent SMARs. (a–c) Rat bronchiole. Double immunocytochemical labelling for Na+/K+-ATPase a3 and the calcium-binding protein calretinin (CRT), reveals a Na+/K+-ATPase a3-ir SMAR. CRT IR is present in the SMAR and in some additional Na+/K+-ATPase a3-negative nerve fibres (open arrows). 5 IR 30 Smooth Muscle-Associated Airway Receptors Therefore, calcium-binding protein immunostaining may not be a sufficiently reliable marker for SMARs.
C) Mouse bronchiole double immunostained for the mechano-gated K+ channel TRAAK and for aSMA. TRAAK-ir SMAR terminals (arrowhead) are located in the airway smooth muscle. L: airway lumen; E: epithelium. (d, e) Rat (d) and mouse (e) bronchioles double stained for SMAR markers and for MBP, showing that the myelin sheath disappears (open arrowhead) just before branching of the nerve fibre (arrow) that gives rise to the SMAR endings (arrowheads). (f, g) Double immunocytochemical staining for the mouse SMAR marker TRAAK and for SV2 showing an abundance of SV2-ir nerve fibres (open arrows) in the airway wall.
1997). Retrograde tracing from the lungs (Springall et al. 1987) and denervation studies revealed that the CGRP-ir nerve fibre population of rat pulmonary NEBs is ä Fig. 6 (continued) especially VGLUT2 is an excellent marker for the vagal sensory innervation of rat NEBs. (e, f) CB-ir NEB cells are in abundant contact with laminar VGLUT1-ir vagal sensory nerve terminals (arrowheads). VGLUT1 fluorescence is very intense in the nerve terminals, but less in the approaching nerve fibre (arrow), which can be visualised by CB IR.
Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors by Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen