New PDF release: Novel Targets in Breast Disease

By Stan Lipkowitz

ISBN-10: 1417511524

ISBN-13: 9781417511525

ISBN-10: 1586033557

ISBN-13: 9781586033552

This paintings is dedicated to cures that make the most of molecular pursuits proper to breast melanoma - so referred to as novel molecular cures. It provides a sampling of either previous and new molecularly special remedies which are being built.

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Extra info for Novel Targets in Breast Disease

Sample text

Cyclin E/CDK2 activity remains indispensable [69]. In addition, in the last few years a second isoform of cyclin E called cyclin E2 has been described [70]. and other splice variants of cyclin E have also been observed in breast cancer, although, specific roles for these variants have not yet been established [71-73].

Brenner. M. Dubinett. S. C. Boucher. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Bio! 21 (1999). 238-245. M. Keane. Y. Rubinstein. M. Cuello. A. Ettenberg. P. Banerjee. M. Nau and S. Lipkowitz. Inhibition of NFkappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. Breast Cancer Res Treat 64 (2000). 211-219. 25 Farnesyltransferase inhibitors: Potential therapeutic for inflammatory breast cancer?

Lastly, based on the ability of RhoB to mediate FTI suppression of the survival kinase Akt in certain epithelial cells [59]. it would be interesting to determine whether there is any intersection in IBC tumors or other RhoC-overexpressing breast tumors between a positive FTI response. RhoC overexpression. and Akt suppression. Further work to study the effect of FTIs on Rho-driven neoplastic or G. C. Prendergast / Farnes\itransferase inhibitors: Potential therapeutic for inflammatory breast cane nonneoplastic diseases will help assess the predictive power and usefulness of the RhoB model for directing clinical applications.

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Novel Targets in Breast Disease by Stan Lipkowitz


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