Read e-book online Nutrition in Epigenetics PDF

By Mihai D. Niculescu, Paul Haggarty

ISBN-10: 0470959827

ISBN-13: 9780470959824

ISBN-10: 081381605X

ISBN-13: 9780813816050

The learn of epigenetics, or how heritable alterations in gene expression are regulated with out enhancing the coding DNA series, has develop into an more and more very important box of analysis lately. speedy advancements in our knowing of how during which gene functionality is modulated by way of the surroundings has revolutionized the best way we expect approximately human improvement and well-being. Nutrition in Epigenetics studies the most recent learn the interplay among genes and nutrition and the function they play jointly in protecting human well-being.

Nutrition in Epigenetics is split into fundamental elements. the 1st half presents key rules reminiscent of epigenetic mechanisms, developmental epigenetics, and the function of epigenetics in affliction. the second one half appears to be like particularly on the software of epigenetics to the sphere of human meals. Chapters evaluate the position of particular food in modulating epigenetic prestige and the impact on health and wellbeing and disorder.

Nutrition in Epigenetics is an critical source for researchers, execs and complex scholars with an curiosity in human meals, epigenetics, and biomedical research.Content:
Chapter 1 creation (pages 1–7): Mihai D. Niculescu and Paul Haggarty
Chapter 2 DNA Methylation (pages 9–45): Natalia V. Cucu
Chapter three Chromatin alterations (pages 47–71): Sandra B. Hake
Chapter four Roles of RNAi and different Micro?RNAs within the law of Epigenetic approaches (pages 73–86): Muller Fabbri
Chapter five Epigenetic Inheritance: either Mitotic and Meiotic (pages 87–103): Nina J. Kaminen?Ahola, Arttu I. Ahola and Emma Whitelaw
Chapter 6 Developmental Epigenetics: Roles in Embryonic improvement (pages 105–126): Liliana Burlibasa and Lucian Gavrila
Chapter 7 Epigenetics, foodstuff, and melanoma (pages 127–143): Amy R. Johnson
Chapter eight Metabolic Syndrome, weight problems, and Diabetes (pages 145–164): Karen D. Corbin
Chapter nine Autoimmunity (pages 165–171): Donna Ray and Raymond Yung
Chapter 10 Cardiovascular illnesses (pages 173–187): Aurelian Bidulescu and Methode Bacanamwo
Chapter eleven Maternal meals and Developmental results (pages 189–208): Shannon L. Haley, Laurie J. Moyer?Mileur, Robert H. Lane and Lisa A. Joss?Moore
Chapter 12 Folate, diet B12, and diet B6 (pages 209–223): Patrick J. Stover
Chapter thirteen nutritional Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing mind improvement (pages 225–240): Steven H. Zeisel
Chapter 14 Epigenetic law via Retinoids (pages 241–248): Amandio Vieira
Chapter 15 we're what we consume: How dietary Compounds comparable to Isoflavones form Our Epigenome (pages 249–261): Carlos M. Guerrero?Bosagna and Susan J. Clark
Chapter sixteen Isothiocyanates and Polyphenols (pages 263–272): Nigel J. Belshaw and Ian T. Johnson
Chapter 17 The impression of Maternal Macronutrient consumption on Phenotype Induction and Epigenetic Gene legislation (pages 273–285): Karen A. Lillycrop, Mark A. Hanson and Graham C. Burdge
Chapter 18 Epigenetic Manifestation of Environmental Exposures (pages 287–307): Dana C. Dolinoy, Olivia S. Anderson and Laura S. Rozek
Chapter 19 Epigenetics, nutrients, and copy: brief? and Long?Term outcomes (pages 309–328): Paul Haggarty
Chapter 20 meals, Epigenetics, and melanoma: An Epidemiological standpoint (pages 329–343): Audrey Jung and Ellen Kampman

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Workshop on epigenetics and chromatin: transcriptional regulation and beyond. EMBO Rep 6: 624–628. , Corn, P. , Baylin, S. , Herman, J. G. (2001a) A gene hypermethylation profile of human cancer. Cancer Res 8: 3225–3229. , Fraga, M. , Godwin, A. , Canal, M. , Peinado, M. , Aaltonen, L. , Ponder, B. , Baylin, S. , Herman, J. G. (2001b) DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet 10(26): 3001–3007. , Fraga, M. , Paz, M. , Novo, F. , Calasanz, M.

Bestor, T. , Kolsto, A. , Prydz, H. (1992) CpG islands in mammalian gene promoters are inheritently resistant to de novo methylation. Genet Anal Tech Appl 9: 48–53. Bhattacharaya, S. , Szyf, M. (1999) A mammalian protein with specific demethylase activity for mCpG DNA. Nature 397: 579–583. , Karran, P. (2005) Unmasking a killer: DNA O-methylguanine and the cytotoxicity of methylationg agents. Mutat Res 462(2–3): 71–82. P1: SBT Color: 1C BLBS079-02 BLBS079-Niculescu 36 March 17, 2011 10:53 Trim: 244mm X 172mm Nutrition in Epigenetics Bird, A.

Li, F. (2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltrannsferases to establish maternal imprints in mice. Development 129: 1983–1993. , Bird, A. (1999) The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 401: 301–304. , Jeltsch, A. (2004a) Biochemistry and biology of DNA mammalian DNA methyltransferases. Curr Mol Life Sci 61: 2571–2587. , Jeltsch, A. (2004b) The Dnmt1 DNA -(cytosine C5)-methyltransferase methylates DNA processivly with high preference for hemimethylated target sites.

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Nutrition in Epigenetics by Mihai D. Niculescu, Paul Haggarty

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