By Julia A. McMillan, Lippincott Williams & Wilkins,
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Additional resources for Oski's Pediatrics - Pediatrics Principles and Practice
Diagnosis is made through culture of the organism from urine or tissue. Progression to severe chronic liver disease is rare. Severe disease may be treated with ganciclovir. Herpes Simplex: Jaundice and massive hepatic necrosis with liver failure may occur. Coxsackievirus and echovirus (types 11, 14, and 19) infection may present similarly. Diagnosis is made through viral isolation and serology. Documented infection is treated with adenine arabinoside or acyclovir. Syphilis: Eighty percent have hepatomegaly, and 40% are jaundiced.
The disorder appears to be acquired rather than a result of abnormal development, based on the rarity of biliary atresia in autopsied fetuses and premature newborns. One causative factor is believed to be infection with reovirus type 3. CLIN: Infants with biliary atresia are typically born at term and have a normal birth weight. Jaundice develops at age 3 to 6 weeks in otherwise well-appearing, thriving infants. , splenic tissue divided into several equally sized masses), cardiovascular anomalies, and malrotation of the intestine.
Assistant Professor of Pediatrics Baylor College of Medicine Houston, Texas Charles E. D. D. Attending Physician Department of Pediatrics Kaiser Permanente Los Angeles Medical Center Los Angeles, California James P. D. Associate Professor of Pediatrics, Medicine, and Microbiology and Immunology University of Maryland School of Medicine Baltimore, Maryland William H. D. Professor of Pediatrics University of Pittsburgh School of Medicine Director, Pediatric Cardiology Children’s Hospital of Pittsburgh Pittsburgh, Pennsylvania Bruce G.
Oski's Pediatrics - Pediatrics Principles and Practice by Julia A. McMillan, Lippincott Williams & Wilkins,