By Earl J. Brown
This distinct try prep advisor lets you organize for pathology, the most heavily-tested topics at the USMLE Step 1 - together with present advances in molecular pathogenesis and the pathophysiology of disorder; perform with 500 USMLE Step 1-style questions with referenced solutions; assessment motives for correct and fallacious solutions; and construct self assurance, talents, and data.
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Extra info for Pathology: PreTest Self-Assessment and Review (Pretest Series)
Patent ductus arteriosus (PDA) • “machine-like” heart murmur • indomethacin closes PDA b. Right-to-Left Shunts 1. Tetralogy of Fallot (TOF) → most common cause of congenital cyanotic heart disease • pulmonary stenosis • ventricular septal defect • dextropositioned (overriding) aorta • right ventricular hypertrophy c. No Shunts 1. Coarctation of the aorta • infantile type (preductal) • adult type (postductal) → rib notching, increased BP in upper extremities, decreased BP in lower extremities 2.
Type IV 1. Delayed type hypersensitivity • CD4 lymphocytes • extrinsic antigen associated with class II MHC • formation of activated macrophages (epithelioid cells) → granulomas • PPD skin test • contact dermatitis (poison ivy, poison oak) 2. Cell-mediated immunity • CD8 lymphocytes • intrinsic antigen associated with class I MHC • viral infections and transplant rejection 38. AUTOANTIBODIES a. , progressive systemic sclerosis) • centromere → CREST syndrome b. Cytoplasmic • mitochondria → primary biliary cirrhosis c.
Post-streptococcal glomerulonephritis • large, irregular subepithelial deposits ii. type IV lupus nephritis • subendothelial deposits form “wire-loop” lesions c) Membranoproliferative glomerulonephritis (MPGN) • subendothelial deposits → type I MPGN • intramembranous deposits → type II MPGN (dense deposit disease) • splitting of basement membrane by mesangium → “tram-track” appearance d) Rapidly progressive glomerulonephritis (RPGN) 54. GLOMERULAR DEPOSITS a. Subepithelial • diffuse proliferative glomerulonephritis (DPGN) → irregular and large • membranous glomerulonephropathy (MGN) → uniform and small b.
Pathology: PreTest Self-Assessment and Review (Pretest Series) by Earl J. Brown