By William Kemp
Get the large photo of Pathology - and concentrate on what you actually need to understand to attain excessive at the direction and board examination if you would like a streamlined and definitive examine Pathology - one with simply the suitable stability of data to offer you the sting at examination time - flip to Pathology: the large photograph. you will discover a succinct, ordinary presentation in particular designed to make even the main advanced notion comprehensible within the shortest volume of research time attainable. This ideal pictorial and textual review of Pathology gives you: A “Big photo” emphasis on what you want to comprehend verses “what's great to understand” professional authorship by way of award-winning, energetic teachers assurance of the total diversity of pathology subject matters - every little thing from mobile diversifications and damage to genetic problems to irritation to ailments of immunity extraordinary 4-color illustrations a number of precis tables and figures for fast reference and quick retention of even the main tough subject Highlighted key techniques that underscore essential facets of histology (key strategies also are indexed in a desk on the finish of every bankruptcy) USMLE-type questions, solutions, and causes that can assist you count on what you are going to stumble upon at the checks and lots more and plenty extra!
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Retinoblastoma (RB) gene • Associated neoplasms: Familial retinoblastoma and osteosarcoma; breast cancer and small cell lung carcinoma. • Role of normal RB gene: Retinoblastoma binds E2F transcription factor, which is needed for the cell to move from the G1 phase of the cell cycle to the S phase. When retinoblastoma is phosphorylated, the E2F is released and the cell moves through the cell cycle.
P24 major capsid protein. ■ gag gene encodes p24. ■ pol gene encodes reverse transcriptase. Mechanism of HIV infection ■ gp120 binds to CD4, which exposes the site for CXCR4 on T cells and for CCR5 on macrophages. Then, gp41 undergoes a change, which allows it to insert into the target membrane, allowing viral-cell fusion. ■ Viral core enters the cell; the viral genome then undergoes reverse transcription. In dividing cells, the cDNA enters the nucleus and integrates into the viral genome. ■ When the infected cell is activated, proviral transcription occurs, which results in lysis of cells.
There are benign neoplasms, and there are malignant neoplasms). Nomenclature for general categories of neoplasms ■ Adenoma: Benign neoplasm derived from glandular cells. ■ Carcinoma: Malignant neoplasm derived from epithelial cells (Figures 4-1 and 4-2). , fat, muscle). ■ Lymphoma: Malignant neoplasm derived from lymphocytes. ■ Melanoma: Malignant neoplasm derived from melanocytes. ■ Germ cell tumor: Malignant neoplasm derived from germ cells. 35 Copyright © 2008 by The McGraw-Hill Companies, Inc.
Pathology: The Big Picture by William Kemp