By Arthur Zimmermann, Marcio Malogolowkin, Giorgio Perilongo, Dietrich Schweinitz
The box of liver tumors in teenagers, and specifically hepatoblastoma in babies and kids, has noticeable super healing advances over contemporary years. This has been accomplished via an improved figuring out of the biology of affliction, more desirable diagnostic strategies, sophisticated tools of pretreatment tumor staging, the implementation of hugely effective chemotherapy and surgical procedure, targeted tracking of toxicity, and cautious follow-up concepts. overseas managed trials have performed a key position in those advances, and plenty of best figures within the trials are one of the editors and authors of this e-book. Their important objective in Hepatic Tumors in little ones is to supply the reader with a whole replace in this advanced and speedily evolving box. All points of a magnificent good fortune tale are coated, disclosing how the result of a formerly devastating affliction has been so dramatically superior. This ebook will turn out crucial interpreting for all who're serious about the care of kids with liver tumors.
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Extra resources for Pediatric Liver Tumors
Cancer 64: 1169–1176 Bulterys M, Goodman MT, Smith MA et al (1999) Cancer incidence, survival among children, adolescents: United States SEER Program 1975–1995. SEER program, NIH Pub No 99-4649:91–97 Chang MH, Chen CJ, Lai MS et al (1997) Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 336:1855–1859 Chang MH, Chen TH, Hsu HM et al (2005) Taiwan Childhood HCC Study Group. Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems.
An alternative hypothesis was suggested by Latini (2004) who proposed that exposure to di-(2-ethylhexyl)phthalate (DEHP) may be a factor. DEHP is a plasticizer widely used in polyvinyl chloride (PVC), medical, and many consumer products. Leaching of DEHP from these products is known to occur and prenatal exposure appears to be associated with shorter gestation (Whyatt et al. 2009; Latini et al. 2003). Furthermore, in experimental models DEHP is a rodent hepatocarcinogen (Maloney and Waxman 1999).
Carcinogenesis 14:1545–1548 Birch JM (2000) Diagnostic review and classification of solid tumours, in the United Kingdom Childhood Cancer Study: objectives, materials and methods. Br J Cancer 82(5): 1073–1102 Birch JM and Alston RD (2010) Incidence, spectrum and relative frequency of liver tumours in children and adolescents in England, 1990–2006 (in preparation) Boffetta P, Tredaniel J, Greco A (2000) Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: a meta-analysis.
Pediatric Liver Tumors by Arthur Zimmermann, Marcio Malogolowkin, Giorgio Perilongo, Dietrich Schweinitz