New PDF release: Pharmacogenetics of Breast Cancer: Towards the

By Brian Leyland-Jones

ISBN-10: 1420052934

ISBN-13: 9781420052930

Pharmacogenetics is turning into more and more proper within the prognosis, therapy, and restoration of melanoma sufferers. an important challenge dealing with oncologists is the phenomenal various efficacy of remedy. Promising advances in pharmacogenetics have allowed the improvement of potent brokers as a way to allow custom-made melanoma chemotherapy to develop into regimen for the medical perform. Written by means of specialists within the box and mixing info that's not able to be present in a unmarried resource quantity, Pharmacogenetics of Breast melanoma: combines a whole evaluation of pharmacogenetics and the way it pertains to breast oncology for analysis, remedy, and the restoration of sufferers utilizing an individualized treatment version is the 1st unmarried resource reference demonstrating the appliance of pharmacogenetics within the care of breast melanoma sufferers allows physicians a coherent interpretation of the rising technology of pharmacogenetics, helping them to include person cures of their personal perform provides useful counsel on quite a few sorts of specimen assortment, tissue choice, and dealing with systems

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Extra resources for Pharmacogenetics of Breast Cancer: Towards the Individualization of Therapy (Translational Medicine)

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J Pharmacol Sci 2005; 97:83–90. 44. Leyseng-Williamson KA, Fenton C. Docetaxel a review of its use in metastatic breast cancer. Drugs 2005; 65:2513–2531. 45. Bahadur N, Leathart JB, Mutch E, et al. CYP2C8 polymorphisms in Caucasions and their relationship with paclitaxel 6 a´- hydroxylase activity in human liver micorsomes. Biochem Pharmacol 2002; 64:1579–1589. 46. Henningsson A, Marsh S, Loos WJ, et al. Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with pharmacokinetics of paclitaxel.

J Clin Oncol 1994; 12:2248–2253. 29. Raida M, Schwabe W, Hausler P, et al. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5’-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 2001; 7:2832–2839. 30. McLeod HL, Collie-Duguid ES, Vreken P, et al. Nomenclature for human DPYD alleles. Pharmacogenetics 1998; 8:455–459. 31. Lu A, Zhang R, Diasio RB. Dihydropyrimadine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

CYP2C9*2, CYP2C9*3, CYP2C19*2, and CYP2C19*3 were not significantly correlated with the metabolism of CP in 19 human liver specimens (11). Phase II drug metabolism is catalyzed by GSTs, which consist of several isoenzymes, including mu (GSTM1), pi (GSTP1), alpha (GSTA1), theta (GSTT1), and zeta. The GSTs detoxify many chemotherapeutic drugs, including CP, are induced by oxidative stress, and detoxify the reactive oxygen species (ROS) that are produced by chemotherapeutic drugs and radiation therapy.

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Pharmacogenetics of Breast Cancer: Towards the Individualization of Therapy (Translational Medicine) by Brian Leyland-Jones


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