By A Arimura (auth.), Hubert Vaudry, Akira Arimura (eds.)
Pituitary Adenylate Cyclase-Activating Polypeptide is the 1st quantity to be written at the neuropeptide PACAP. It covers all domain names of PACAP from molecular and mobile elements to physiological actions and grants for brand spanking new healing options.
Pituitary Adenylate Cyclase-Activating Polypeptide is the 20 th quantity released within the Endocrine Updates publication sequence less than the sequence Editorship of Shlomo Melmed, MD.
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Additional info for Pituitary Adenylate Cyclase-Activating Polypeptide
The tissue distribution pattern of the frog VPAC2-R correlates well with the functions of VIP as an important non-adrenergic-non-cholinergic inhibitory neurotransmitter in the brain, as well as a physiological regulator of water and electrolytes secretion in the gastrointestinal tract. 4. Phylogenetic analysis and evolution of the PACAP receptors in vertebrates Similar to the PACAP precursors, the structure of PACAP receptors has been remarkably conserved during evolution from teleosts to mammals.
RNA blot analysis revealed that VPAC2-R mRNA is expressed at high levels in MIN6, at moderate levels in pancreatic islets and other insulin-secreting cell lines, as well as in the lung, brain, stomach, and colon, and at low levels in the heart. (Jnagaki et aI, 1994). Human VPAC2-R cDNA was also cloned (Svoboda et aI, 1994; Adamou et aI, 1995). The deduced protein consists of 438 amino acids. Human and rat VPAC2-R have 87% similarity (Gagnon et aI, 1994; Svoboda et aI, 1994; Adamou et aI, 1995).
Molecular cloning and functional characterization of a human VIP receptor from SUP-Tl Iymphoblasts. Biochem Biophys Res Commun 1994;205: 1617-1624. Tabuchi A, Koizumi M, Tsuda M. Novel splice variants of PACAP gene in mouse cerebellar granule cells. Neuroreport 2001 ;12:1181-1186. Torii S, Yamagishi T, Murakami K, Nakayama K. Localization of Kex2-like processing endoproteases, furin and PC4 within muse testis by in situ hybridization. FEBS LettersI992;316: 12-16. Tsukada T, Horovitch SJ, Montminy MR, Mandel G, Goodman RH.
Pituitary Adenylate Cyclase-Activating Polypeptide by A Arimura (auth.), Hubert Vaudry, Akira Arimura (eds.)